Learning under stress in the adult rat is differentially affected by 'juvenile' or 'adolescent' stress

Michael Tsoory, Gal Richter-Levin

Research output: Contribution to journalArticlepeer-review


Epidemiological studies suggest that childhood trauma is associated with a predisposition to develop both mood and anxiety disorders, while trauma during adolescence is associated mainly with anxiety disorders. We studied in the rat the long-term consequences of 'juvenile' stress, namely stress experienced in a period in which substantial remodelling occurs across species in stress-sensitive brain areas involved in emotional and learning processing. In adulthood, 'juvenile' stressed rats exhibited reduced exploration in a novel setting, and poor avoidance learning, with 41% learning mainly to escape while 28% exhibited learned helplessness-like behaviours. In adult rats that underwent 'adolescent' stress, learned helplessness-like behaviours were not evident, although decreased exploration and poor avoidance learning were observed. This suggests that in the prepubertal phase juvenility may constitute a stress-sensitive period. The results suggest that juvenile stress induces lasting impairments in stress-coping responses. The 'juvenile' stress model presented here may be of relevance to individuals' reported predisposition to anxiety and depression following childhood trauma, and their increased susceptibility only to anxiety disorders following adolescent stress.

Original languageEnglish
Pages (from-to)713-728
Number of pages16
JournalInternational Journal of Neuropsychopharmacology
Issue number6
StatePublished - Dec 2006

Bibliographical note

Funding Information:
We thank Mrs. Gy. Nyiri, Mrs. M. Homok and Mrs. E. Botos for the technical assistance. We are grateful to Heiko Metzner who identified Yl/enus vittatus. The project was financed by a USDA Grant (No. 58-319R-3-022). F. Samu was supported by the OTKA grant No. F 017691 and by the Magyary Zoltan Fellowship scheme. The other authors were supported by the OTKA grant No. 1436.


  • Adolescent
  • Juvenile
  • Rat
  • Stress

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)


Dive into the research topics of 'Learning under stress in the adult rat is differentially affected by 'juvenile' or 'adolescent' stress'. Together they form a unique fingerprint.

Cite this