Learning-induced enhancement of feedback inhibitory synaptic transmission

Inbar Brosh, Edi Barkai

Research output: Contribution to journalArticlepeer-review


Olfactory-discrimination learning results with a series of intrinsic and excitatory synaptic modifications in piriform cortex pyramidal neurons. Here we show that such learning results with long-lasting enhancement of inhibitory synaptic transmission onto proximal dendrites of these pyramidal neurons. Such enhancement is mediated by a strong hyperpolarizing shift in the reversal potential of fast inhibitory postsynaptic potentials (fIPSPs). Moreover, paired-pulse depression of these IPSPs, indicating enhanced GABA release, is also apparent after learning. We suggest that learning is accompanied by long-lasting enhancement of synaptic inhibition onto excitatory neurons, thus compensating for the increase of excitation in these neurons.

Original languageEnglish
Pages (from-to)413-416
Number of pages4
JournalLearning and Memory
Issue number7
StatePublished - Jul 2009

ASJC Scopus subject areas

  • General Medicine


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