Learning-induced changes in mpfc-bla connections after fear conditioning, extinction, and reinstatement of fear

Rose Marie Vouimba, Mouna Maroun

Research output: Contribution to journalArticlepeer-review


The neural circuit linking the medial prefrontal cortex (mPFC) and the basolateral amygdala (BLA) has crucial roles in both the acquisition and the extinction of fear. However, the mechanism by which this circuit encodes fear and extinction remains unknown. In this study, we monitored changes in the magnitude of evoked field potentials (EFPs) in the mPFC-BLA and BLA-mPFC pathways following auditory fear conditioning and extinction, in freely moving rats. We report that extinction of fear is mediated by depression of the EFPs in the mPFC-BLA and by potentiation in the reciprocal pathway of BLA-mPFC. Interestingly, reinstatement of fear was associated with recovery of freezing and with reversal of the changes in EFPs that were observed following extinction in both pathways. The findings indicate that the mPFC-BLA circuit expresses differential changes following fear and extinction and point to dynamic and plastic changes underlying fear, extinction, and reinstatement. Manipulations targeting these different types of plasticity could constitute a therapeutic tool for the treatment of anxiety disorders.

Original languageEnglish
Pages (from-to)2276-2285
Number of pages10
Issue number11
StatePublished - Oct 2011

Bibliographical note

Funding Information:
We thank Professor Rene Garcia for his critical and valuable comments on the MS. This work was supported by the Israel Science Foundation (ISF, grant # 469/07) to MM.


  • BLA
  • Fear
  • extinction
  • mPFC
  • reinstatement

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology


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