Learning Context-Dependent DNA Mutation Patterns in Error-Prone Polymerase Chain Reaction

Research output: Contribution to journalArticlepeer-review

Abstract

We present a novel statistical learning method for studying context-dependent error rates in error-prone polymerase chain reaction (PCR) experiments. We demonstrate the method by applying it to error-prone PCR sequencing data and show how it may be exploited to improve the evolvability of genes in protein engineering.

Original languageEnglish
Number of pages6
JournalBiochemistry
Volume62
Issue number2
Early online date26 Sep 2022
DOIs
StatePublished - 17 Jan 2023

Bibliographical note

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ASJC Scopus subject areas

  • Biochemistry

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