Learning Context-Dependent DNA Mutation Patterns in Error-Prone Polymerase Chain Reaction

Research output: Contribution to journalArticlepeer-review

Abstract

We present a novel statistical learning method for studying context-dependent error rates in error-prone polymerase chain reaction (PCR) experiments. We demonstrate the method by applying it to error-prone PCR sequencing data and show how it may be exploited to improve the evolvability of genes in protein engineering.

Original languageEnglish
JournalBiochemistry
DOIs
StateAccepted/In press - 2022

Bibliographical note

Publisher Copyright:
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ASJC Scopus subject areas

  • Biochemistry

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