Lateralized neuroleptic-induced side effects are associated with asymmetric visual evoked potentials

Rachel Tomer; Matti Mintz; Shmuel Kempler; Mircea Sigal

doi:10.1016/0165-1781(87)90110-7

Lateralized neuroleptic-induced side effects are associated with asymmetric visual evoked potentials

Rachel Tomer, Matti Mintz, Shmuel Kempler, Mircea Sigal

Research output: Contribution to journal › Article › peer-review

Abstract

Recent studies suggest that neuroleptic drugs may have an asymmetric effect on the two cerebral hemispheres. This effect is reflected by emergence of drug-induced lateralized extrapyramidal side effects and by dose-related alterations in electrophysiological asymmetries. The present study examined the hypothesis that asymmetry of visual evoked potentials (VEPs) is associated with lateralized appearance of neuroleptic-induced parkinsonism or tardive dyskinesia (TD). The asymmetry of the amplitudes of later VEP components was significantly higher in patients with lateralized side effects (n=8) than in patients with symmetrical side effects (n=6) or free of extrapyramidal side effects (n=11). The possibility that VEP asymmetry reflects the differential degree to which the two hemispheres are affected by medication is discussed.

Original language	English
Pages (from-to)	311-318
Number of pages	8
Journal	Psychiatry Research
Volume	22
Issue number	4
DOIs	https://doi.org/10.1016/0165-1781(87)90110-7
State	Published - Dec 1987
Externally published	Yes

Keywords

Tardive dyskinesia
hemispheric asymmetry
lateralized side effects
neuroleptics
parkinsonian side effects
visual evoked potentials

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/0165-1781(87)90110-7

Cite this

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title = "Lateralized neuroleptic-induced side effects are associated with asymmetric visual evoked potentials",

abstract = "Recent studies suggest that neuroleptic drugs may have an asymmetric effect on the two cerebral hemispheres. This effect is reflected by emergence of drug-induced lateralized extrapyramidal side effects and by dose-related alterations in electrophysiological asymmetries. The present study examined the hypothesis that asymmetry of visual evoked potentials (VEPs) is associated with lateralized appearance of neuroleptic-induced parkinsonism or tardive dyskinesia (TD). The asymmetry of the amplitudes of later VEP components was significantly higher in patients with lateralized side effects (n=8) than in patients with symmetrical side effects (n=6) or free of extrapyramidal side effects (n=11). The possibility that VEP asymmetry reflects the differential degree to which the two hemispheres are affected by medication is discussed.",

keywords = "Tardive dyskinesia, hemispheric asymmetry, lateralized side effects, neuroleptics, parkinsonian side effects, visual evoked potentials",

author = "Rachel Tomer and Matti Mintz and Shmuel Kempler and Mircea Sigal",

year = "1987",

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doi = "10.1016/0165-1781(87)90110-7",

language = "English",

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T1 - Lateralized neuroleptic-induced side effects are associated with asymmetric visual evoked potentials

AU - Tomer, Rachel

AU - Mintz, Matti

AU - Kempler, Shmuel

AU - Sigal, Mircea

PY - 1987/12

Y1 - 1987/12

N2 - Recent studies suggest that neuroleptic drugs may have an asymmetric effect on the two cerebral hemispheres. This effect is reflected by emergence of drug-induced lateralized extrapyramidal side effects and by dose-related alterations in electrophysiological asymmetries. The present study examined the hypothesis that asymmetry of visual evoked potentials (VEPs) is associated with lateralized appearance of neuroleptic-induced parkinsonism or tardive dyskinesia (TD). The asymmetry of the amplitudes of later VEP components was significantly higher in patients with lateralized side effects (n=8) than in patients with symmetrical side effects (n=6) or free of extrapyramidal side effects (n=11). The possibility that VEP asymmetry reflects the differential degree to which the two hemispheres are affected by medication is discussed.

AB - Recent studies suggest that neuroleptic drugs may have an asymmetric effect on the two cerebral hemispheres. This effect is reflected by emergence of drug-induced lateralized extrapyramidal side effects and by dose-related alterations in electrophysiological asymmetries. The present study examined the hypothesis that asymmetry of visual evoked potentials (VEPs) is associated with lateralized appearance of neuroleptic-induced parkinsonism or tardive dyskinesia (TD). The asymmetry of the amplitudes of later VEP components was significantly higher in patients with lateralized side effects (n=8) than in patients with symmetrical side effects (n=6) or free of extrapyramidal side effects (n=11). The possibility that VEP asymmetry reflects the differential degree to which the two hemispheres are affected by medication is discussed.

KW - Tardive dyskinesia

KW - hemispheric asymmetry

KW - lateralized side effects

KW - neuroleptics

KW - parkinsonian side effects

KW - visual evoked potentials

UR - https://www.scopus.com/pages/publications/0023584250

U2 - 10.1016/0165-1781(87)90110-7

DO - 10.1016/0165-1781(87)90110-7

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AN - SCOPUS:0023584250

SN - 0165-1781

VL - 22

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EP - 318

JO - Psychiatry Research

JF - Psychiatry Research

IS - 4

ER -

Lateralized neuroleptic-induced side effects are associated with asymmetric visual evoked potentials

Abstract

Keywords

ASJC Scopus subject areas

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