Lack of association between contraceptive usage and congenital malformations in offspring

Shai Linn, Stephen C. Schoenbaum, Richard R. Monson, Bernard Rosner, Phillip G. Stubblefield, Kenneth J. Ryan

Research output: Contribution to journalArticlepeer-review


Previous reports have linked the use of oral contraceptives and spermicides to the occurrence of malformations in offspring. With information from 12,440 women interviewed during the delivery hospitalization we found no relationship between contraceptive method and the occurrence of malformations. Whereas any unnecessary drug should be avoided during pregnancy, prior contraceptive method seems to be unrelated to the risk of congenital malformations.

Original languageEnglish
Pages (from-to)923-928
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Issue number8
StatePublished - 15 Dec 1983
Externally publishedYes

Bibliographical note

Funding Information:
From the Departments of Medicine and Obstetrics and Gynecology, Brigham and Women’s Hospital and Harvard Medical School, and the Department of Epidemiology, Harvard School of Public Health. Funds for the design and the collection of data for this study were provided by a grant from the National Birth Defects Foundation. Additional funds for the analyses in this paper were provided by O&o Pharmaceutical Co@wation. Received for publication February I I, 1983. Revised July 29, 1983. Accepted August 15, 1983. Reprint requests: Kenneth J. Ryan, M.D., Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, 75 Francis St., Boston, Massachusetts 02115.

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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