Widespread use of artificial light at night (ALAN) might contribute to the global burden of hormone-dependent cancers. Previous attempts to verify this association in population-level studies have been sparse. Using GLOBOCAN, US-DMSP, and World Bank 2010–2012 databases, we studied the association between ALAN and prostate cancer (PC) incidence in 180 countries worldwide, controlling for several country-level confounders. The PC–ALAN association emerged marginally significant when year-2012 PC age-standardized rate data were compared with ALAN levels (t = 1.886, p <.1); this association was more significant (t > 2.7; p <.01) when only 110 countries with well-maintained cancer registries were analyzed. Along with other variables, ALAN explains up to 79% of PC ASR variability. PC–ALAN association appears to vary regionally, with the greatest deviations in Central Africa, Small Island Developing States, Southeast Asia, and Gulf States.
Bibliographical notePublisher Copyright:
© 2016 Taylor & Francis.
- Age standardized incidence rates
- artificial light at night (ALAN)
- circadian disruption
- melatonin suppression
- regional differences
- world countries
ASJC Scopus subject areas
- Environmental Science (all)
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis