Is neighborhood deprivation index a risk factor for Staphylococcus aureus infections?

Geeta Sood, Geoff Dougherty, John Martin, Edward Beranek, B. Mark Landrum, Sonia Qasba, Mayank Patel, Christina Wilson, Amanda Miller, Mark Sulkowski, Richard G. Bennett, Cynthia L. Sears, Alyson Schuster, Noya Galai

Research output: Contribution to journalArticlepeer-review

Abstract

Background: We assessed the association between neighborhood area deprivation index (ADI) and community-onset (co) and hospital-onset (ho) Staphylococcus aureus infection. Methods: Demographic and clinical characteristics of patients admitted to 5 adult hospitals in the mid-Atlantic between 2016 and 2018 were obtained. The association of ADI with methicillin-resistant (MRSA) and methicillin-sensitive (MSSA) S aureus infections was assessed using logistic regression models adjusting for severity of illness and days of admission. Results: Overall, increasing ADI was associated with higher odds of co- and ho-MRSA and MSSA infection. In univariate analysis, Black race was associated with 44% greater odds of ho-MRSA infection (odds ratio [OR] 1.44; 95% CI 1.18-1.76) and Asian race (co-MRSA OR 0.355; Confidence Interval (CI) 0.240-0.525; co-MSSA OR 0.718; CI 0.557-0.928) and unknown race (co-MRSA OR 0.470; CI 0.365-0.606; co-MSSA OR 0.699; CI 0.577-0.848) was associated with lower odds of co-MSSA and co-MRSA infections. When both race and ADI were included in the model, Black race was no longer associated with ho-MRSA infections whereas Asian and unknown race remained associated with lower odds of co-MRSA and co-MSSA infection. In the multivariable logistic regression, ADI was consistently associated with increased odds of S aureus infection (co-MRSA OR 1.132; CI 1.064-1.205; co-MSSA OR 1.089; CI 1.030-1.15; ho-MRSA OR 1.29; CI 1.16-1.43: ho-MSSA OR 1.215; CI 1.096-1.346). Conclusions: The area deprivation index is associated with community and hospital-onset MRSA and MSSA infections.

Original languageEnglish
Pages (from-to)1314-1320
Number of pages7
JournalAmerican Journal of Infection Control
Volume51
Issue number12
Early online date20 Jul 2023
DOIs
StatePublished - Dec 2023

Bibliographical note

Publisher Copyright:
© 2023 Association for Professionals in Infection Control and Epidemiology, Inc.

Keywords

  • Adult
  • Cross Infection/epidemiology
  • Humans
  • Methicillin
  • Methicillin-Resistant Staphylococcus aureus
  • Risk Factors
  • Staphylococcal Infections/epidemiology
  • Staphylococcus aureus

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