Intestinal immunity following a combined enhanced inactivated polio vaccine/oral polio vaccine programme in Israel

T. A. Swartz, M. S. Green, R. Handscher, D. Sofer, M. Cohen-Dar, T. Shohat, S. Habib, E. Barak, Z. Dror, E. Somekh, T. Peled-Leviathan, R. Yulzari, A. Libling, E. Mendelson, L. M. Shulman

Research output: Contribution to journalArticlepeer-review


Intestinal immunity was studied in a polio-free community immunised with a combined enhanced inactivated/oral polio vaccine (EIPV/OPV) vaccination programme. Poliovirus excretion was evaluated in three groups of infants primed with a partial (2 EIPV + 2 OPV) or complete (3 EIPV + 3 OPV) dose schedule. Poliovirus replicated in the gut of 59.8-55.8% of infants in the three groups 7 days after administration of an additional OPV dose. Significant decreases in the percent of type-specific-virus excreters appeared after 14 and 21 days for serotypes 1 and 2, and after 21 and 28 days for serotype 3. The percent of excreters was inversely correlated with pre-challenge neutralising antibody (NA) titers (p < 0.05). Intrafamilial virus transmission to mothers and siblings was minimal. The principal factor for interruption of disease and virus transmission in the community was a strong and persistent humoral immunity with immunological memory. A satisfactory level of family hygiene contributed towards breaking the chain of transmission of poliovirus to contacts.

Original languageEnglish
Pages (from-to)1083-1090
Number of pages8
Issue number8
StatePublished - 20 Feb 2008


  • Combined EIPV/OPV vaccination
  • Polio elimination
  • Polio intestinal immunity
  • Vaccination policy

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology (all)
  • Veterinary (all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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