Intestinal immunity following a combined enhanced inactivated polio vaccine/oral polio vaccine programme in Israel

T. A. Swartz; M. S. Green; R. Handscher; D. Sofer; M. Cohen-Dar; T. Shohat; S. Habib; E. Barak; Z. Dror; E. Somekh; T. Peled-Leviathan; R. Yulzari; A. Libling; E. Mendelson; L. M. Shulman

doi:10.1016/j.vaccine.2007.12.021

Intestinal immunity following a combined enhanced inactivated polio vaccine/oral polio vaccine programme in Israel

T. A. Swartz, M. S. Green, R. Handscher, D. Sofer, M. Cohen-Dar, T. Shohat, S. Habib, E. Barak, Z. Dror, E. Somekh, T. Peled-Leviathan, R. Yulzari, A. Libling, E. Mendelson, L. M. Shulman

School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Intestinal immunity was studied in a polio-free community immunised with a combined enhanced inactivated/oral polio vaccine (EIPV/OPV) vaccination programme. Poliovirus excretion was evaluated in three groups of infants primed with a partial (2 EIPV + 2 OPV) or complete (3 EIPV + 3 OPV) dose schedule. Poliovirus replicated in the gut of 59.8-55.8% of infants in the three groups 7 days after administration of an additional OPV dose. Significant decreases in the percent of type-specific-virus excreters appeared after 14 and 21 days for serotypes 1 and 2, and after 21 and 28 days for serotype 3. The percent of excreters was inversely correlated with pre-challenge neutralising antibody (NA) titers (p < 0.05). Intrafamilial virus transmission to mothers and siblings was minimal. The principal factor for interruption of disease and virus transmission in the community was a strong and persistent humoral immunity with immunological memory. A satisfactory level of family hygiene contributed towards breaking the chain of transmission of poliovirus to contacts.

Original language	English
Pages (from-to)	1083-1090
Number of pages	8
Journal	Vaccine
Volume	26
Issue number	8
DOIs	https://doi.org/10.1016/j.vaccine.2007.12.021
State	Published - 20 Feb 2008

Keywords

Combined EIPV/OPV vaccination
Polio elimination
Polio intestinal immunity
Vaccination policy

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vaccine.2007.12.021

Cite this

Swartz, T. A., Green, M. S., Handscher, R., Sofer, D., Cohen-Dar, M., Shohat, T., Habib, S., Barak, E., Dror, Z., Somekh, E., Peled-Leviathan, T., Yulzari, R., Libling, A., Mendelson, E., & Shulman, L. M. (2008). Intestinal immunity following a combined enhanced inactivated polio vaccine/oral polio vaccine programme in Israel. Vaccine, 26(8), 1083-1090. https://doi.org/10.1016/j.vaccine.2007.12.021

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abstract = "Intestinal immunity was studied in a polio-free community immunised with a combined enhanced inactivated/oral polio vaccine (EIPV/OPV) vaccination programme. Poliovirus excretion was evaluated in three groups of infants primed with a partial (2 EIPV + 2 OPV) or complete (3 EIPV + 3 OPV) dose schedule. Poliovirus replicated in the gut of 59.8-55.8% of infants in the three groups 7 days after administration of an additional OPV dose. Significant decreases in the percent of type-specific-virus excreters appeared after 14 and 21 days for serotypes 1 and 2, and after 21 and 28 days for serotype 3. The percent of excreters was inversely correlated with pre-challenge neutralising antibody (NA) titers (p < 0.05). Intrafamilial virus transmission to mothers and siblings was minimal. The principal factor for interruption of disease and virus transmission in the community was a strong and persistent humoral immunity with immunological memory. A satisfactory level of family hygiene contributed towards breaking the chain of transmission of poliovirus to contacts.",

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Swartz, TA, Green, MS, Handscher, R, Sofer, D, Cohen-Dar, M, Shohat, T, Habib, S, Barak, E, Dror, Z, Somekh, E, Peled-Leviathan, T, Yulzari, R, Libling, A, Mendelson, E & Shulman, LM 2008, 'Intestinal immunity following a combined enhanced inactivated polio vaccine/oral polio vaccine programme in Israel', Vaccine, vol. 26, no. 8, pp. 1083-1090. https://doi.org/10.1016/j.vaccine.2007.12.021

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T1 - Intestinal immunity following a combined enhanced inactivated polio vaccine/oral polio vaccine programme in Israel

AU - Swartz, T. A.

AU - Green, M. S.

AU - Handscher, R.

AU - Sofer, D.

AU - Cohen-Dar, M.

AU - Shohat, T.

AU - Habib, S.

AU - Barak, E.

AU - Dror, Z.

AU - Somekh, E.

AU - Peled-Leviathan, T.

AU - Yulzari, R.

AU - Libling, A.

AU - Mendelson, E.

AU - Shulman, L. M.

PY - 2008/2/20

Y1 - 2008/2/20

N2 - Intestinal immunity was studied in a polio-free community immunised with a combined enhanced inactivated/oral polio vaccine (EIPV/OPV) vaccination programme. Poliovirus excretion was evaluated in three groups of infants primed with a partial (2 EIPV + 2 OPV) or complete (3 EIPV + 3 OPV) dose schedule. Poliovirus replicated in the gut of 59.8-55.8% of infants in the three groups 7 days after administration of an additional OPV dose. Significant decreases in the percent of type-specific-virus excreters appeared after 14 and 21 days for serotypes 1 and 2, and after 21 and 28 days for serotype 3. The percent of excreters was inversely correlated with pre-challenge neutralising antibody (NA) titers (p < 0.05). Intrafamilial virus transmission to mothers and siblings was minimal. The principal factor for interruption of disease and virus transmission in the community was a strong and persistent humoral immunity with immunological memory. A satisfactory level of family hygiene contributed towards breaking the chain of transmission of poliovirus to contacts.

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KW - Combined EIPV/OPV vaccination

KW - Polio elimination

KW - Polio intestinal immunity

KW - Vaccination policy

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SN - 0264-410X

VL - 26

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JO - Vaccine

JF - Vaccine

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ER -

Intestinal immunity following a combined enhanced inactivated polio vaccine/oral polio vaccine programme in Israel

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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