Interleukin-1 may link helplessness-hopelessness with cancer progression: A proposed model

Miriam Argaman; Yori Gidron; Shmuel Ariad

doi:10.1207/s15327558ijbm1203_5

Interleukin-1 may link helplessness-hopelessness with cancer progression: A proposed model

Miriam Argaman, Yori Gidron, Shmuel Ariad

Research output: Contribution to journal › Review article › peer-review

Abstract

A model of the relations between psychological factors and cancer progression should include brain and systemic components and their link with critical cellular stages in cancer progression. We present a psychoneuroimmunological (PNI) model that links helplessness-hopelessness (HH) with cancer progression via interleukin-1β (IL-1β). IL-1β was elevated in the brain following exposure to inescapable shock, and HH was minimized by antagonizing cerebral IL-1β. Elevated cerebral IL-1β increased cancer metastasis in animals. Inescapable shock was associated with systemic elevations IL-1β and peripheral IL-1β was associated with escape from apoptosis, angiogenesis, and metastasis. Involvement of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis are discussed. Future studies need to identify the role of additional factors in this PNI pathway.

Original language	English
Pages (from-to)	161-170
Number of pages	10
Journal	International Journal of Behavioral Medicine
Volume	12
Issue number	3
DOIs	https://doi.org/10.1207/s15327558ijbm1203_5
State	Published - 2005
Externally published	Yes

Keywords

Cancer
Hopelessness
IL-1β
Progression
Psychoneuroimmunology

ASJC Scopus subject areas

Applied Psychology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1207/s15327558ijbm1203_5

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title = "Interleukin-1 may link helplessness-hopelessness with cancer progression: A proposed model",

abstract = "A model of the relations between psychological factors and cancer progression should include brain and systemic components and their link with critical cellular stages in cancer progression. We present a psychoneuroimmunological (PNI) model that links helplessness-hopelessness (HH) with cancer progression via interleukin-1β (IL-1β). IL-1β was elevated in the brain following exposure to inescapable shock, and HH was minimized by antagonizing cerebral IL-1β. Elevated cerebral IL-1β increased cancer metastasis in animals. Inescapable shock was associated with systemic elevations IL-1β and peripheral IL-1β was associated with escape from apoptosis, angiogenesis, and metastasis. Involvement of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis are discussed. Future studies need to identify the role of additional factors in this PNI pathway.",

keywords = "Cancer, Hopelessness, IL-1β, Progression, Psychoneuroimmunology",

author = "Miriam Argaman and Yori Gidron and Shmuel Ariad",

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T2 - A proposed model

AU - Argaman, Miriam

AU - Gidron, Yori

AU - Ariad, Shmuel

PY - 2005

Y1 - 2005

N2 - A model of the relations between psychological factors and cancer progression should include brain and systemic components and their link with critical cellular stages in cancer progression. We present a psychoneuroimmunological (PNI) model that links helplessness-hopelessness (HH) with cancer progression via interleukin-1β (IL-1β). IL-1β was elevated in the brain following exposure to inescapable shock, and HH was minimized by antagonizing cerebral IL-1β. Elevated cerebral IL-1β increased cancer metastasis in animals. Inescapable shock was associated with systemic elevations IL-1β and peripheral IL-1β was associated with escape from apoptosis, angiogenesis, and metastasis. Involvement of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis are discussed. Future studies need to identify the role of additional factors in this PNI pathway.

AB - A model of the relations between psychological factors and cancer progression should include brain and systemic components and their link with critical cellular stages in cancer progression. We present a psychoneuroimmunological (PNI) model that links helplessness-hopelessness (HH) with cancer progression via interleukin-1β (IL-1β). IL-1β was elevated in the brain following exposure to inescapable shock, and HH was minimized by antagonizing cerebral IL-1β. Elevated cerebral IL-1β increased cancer metastasis in animals. Inescapable shock was associated with systemic elevations IL-1β and peripheral IL-1β was associated with escape from apoptosis, angiogenesis, and metastasis. Involvement of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis are discussed. Future studies need to identify the role of additional factors in this PNI pathway.

KW - Cancer

KW - Hopelessness

KW - IL-1β

KW - Progression

KW - Psychoneuroimmunology

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DO - 10.1207/s15327558ijbm1203_5

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Interleukin-1 may link helplessness-hopelessness with cancer progression: A proposed model

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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