Insomnia Due to Drug or Substance Abuse and Dependence

I. S. Hairston, N. Z. Akbar, D. A. Conroy

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Chronic use and cessation of use of most reported substances are associated with significant sleep disturbance. Studies on tobacco and marijuana smokers, cocaine and opiate addiction, and recovering alcoholics all find sleep problems during use and withdrawal. The diagnosis of substance use related insomnia requires that the sleep difficulty be etiologically associated with substance use, but clinically distinct from the acute effects of the substance or symptoms of withdrawal. Indeed, changes in sleep patterns often persist beyond the immediate withdrawal symptoms, suggesting that chronic drug exposure and the development of addiction may interfere with mechanisms involved in sleep regulation. While there is increasing awareness of the protracted sleep difficulty during abstinence, there is scant understanding of the underlying neurophysiology, and treatment options are limited.

Original languageEnglish
Title of host publicationEncyclopedia of Sleep
ISBN (Electronic)9780123786111
ISBN (Print)9780123786104
StatePublished - 1 Jan 2013
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2013 Elsevier Inc. All rights reserved.


  • Addiction
  • Central nervous system stimulants
  • Dopamine
  • GABA
  • Mesolimbic system

ASJC Scopus subject areas

  • General Medicine
  • General Neuroscience


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