Influence of encapsulated heat shock protein HSP70 on the basic functional properties of blood phagocytes

O. Yu Kochetkova; M. M. Yurinskaya; M. B. Evgen’ev; O. G. Zatsepina; L. I. Shabarchina; A. V. Suslikov; S. A. Tikhonenko; M. G. Vinokurov

doi:10.1134/S001249661506006X

Influence of encapsulated heat shock protein HSP70 on the basic functional properties of blood phagocytes

O. Yu Kochetkova
, M. M. Yurinskaya
, M. B. Evgen’ev
, O. G. Zatsepina
, L. I. Shabarchina
, A. V. Suslikov
, S. A. Tikhonenko
, M. G. Vinokurov

Research output: Contribution to journal › Article › peer-review

Abstract

Microencapsulated heat shock proteins HSP 70 were studied in terms of their effects on neutrophil apoptosis, production of reactive oxygen species, and secretion of TNF-α by human neurtrophils and monocytes. Encapsulated HSP70 inhibited neutrophil apoptosis by 65% as compared to the effect of nonencapsulated HSP70; TNF-α production by the promonocytic THP-1 cells was similarly inhibited by the non-encapsulated and encapsulated HSP70. Thus, the polyelectrolyte micromolecules can be used as containers for effective delivery of HSP70 up to neutrophils and monocytes to correct the innate immunity functions.

Original language	English
Pages (from-to)	299-302
Number of pages	4
Journal	Doklady Biological Sciences
Volume	465
Issue number	1
DOIs	https://doi.org/10.1134/S001249661506006X
State	Published - 1 Nov 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015, Pleiades Publishing, Ltd.

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
General Agricultural and Biological Sciences

Access to Document

10.1134/S001249661506006X

Cite this

@article{a9c3d71e370a481bbdc83fde3073a716,

title = "Influence of encapsulated heat shock protein HSP70 on the basic functional properties of blood phagocytes",

abstract = "Microencapsulated heat shock proteins HSP 70 were studied in terms of their effects on neutrophil apoptosis, production of reactive oxygen species, and secretion of TNF-α by human neurtrophils and monocytes. Encapsulated HSP70 inhibited neutrophil apoptosis by 65\% as compared to the effect of nonencapsulated HSP70; TNF-α production by the promonocytic THP-1 cells was similarly inhibited by the non-encapsulated and encapsulated HSP70. Thus, the polyelectrolyte micromolecules can be used as containers for effective delivery of HSP70 up to neutrophils and monocytes to correct the innate immunity functions.",

author = "Kochetkova, \{O. Yu\} and Yurinskaya, \{M. M.\} and Evgen{\textquoteright}ev, \{M. B.\} and Zatsepina, \{O. G.\} and Shabarchina, \{L. I.\} and Suslikov, \{A. V.\} and Tikhonenko, \{S. A.\} and Vinokurov, \{M. G.\}",

note = "Publisher Copyright: {\textcopyright} 2015, Pleiades Publishing, Ltd.",

year = "2015",

month = nov,

day = "1",

doi = "10.1134/S001249661506006X",

language = "English",

volume = "465",

pages = "299--302",

journal = "Doklady Biological Sciences",

issn = "0012-4966",

publisher = "Pleiades Publishing",

number = "1",

}

TY - JOUR

T1 - Influence of encapsulated heat shock protein HSP70 on the basic functional properties of blood phagocytes

AU - Kochetkova, O. Yu

AU - Yurinskaya, M. M.

AU - Evgen’ev, M. B.

AU - Zatsepina, O. G.

AU - Shabarchina, L. I.

AU - Suslikov, A. V.

AU - Tikhonenko, S. A.

AU - Vinokurov, M. G.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Microencapsulated heat shock proteins HSP 70 were studied in terms of their effects on neutrophil apoptosis, production of reactive oxygen species, and secretion of TNF-α by human neurtrophils and monocytes. Encapsulated HSP70 inhibited neutrophil apoptosis by 65% as compared to the effect of nonencapsulated HSP70; TNF-α production by the promonocytic THP-1 cells was similarly inhibited by the non-encapsulated and encapsulated HSP70. Thus, the polyelectrolyte micromolecules can be used as containers for effective delivery of HSP70 up to neutrophils and monocytes to correct the innate immunity functions.

AB - Microencapsulated heat shock proteins HSP 70 were studied in terms of their effects on neutrophil apoptosis, production of reactive oxygen species, and secretion of TNF-α by human neurtrophils and monocytes. Encapsulated HSP70 inhibited neutrophil apoptosis by 65% as compared to the effect of nonencapsulated HSP70; TNF-α production by the promonocytic THP-1 cells was similarly inhibited by the non-encapsulated and encapsulated HSP70. Thus, the polyelectrolyte micromolecules can be used as containers for effective delivery of HSP70 up to neutrophils and monocytes to correct the innate immunity functions.

UR - https://www.scopus.com/pages/publications/84952877808

U2 - 10.1134/S001249661506006X

DO - 10.1134/S001249661506006X

M3 - Article

C2 - 26725241

AN - SCOPUS:84952877808

SN - 0012-4966

VL - 465

SP - 299

EP - 302

JO - Doklady Biological Sciences

JF - Doklady Biological Sciences

IS - 1

ER -

Influence of encapsulated heat shock protein HSP70 on the basic functional properties of blood phagocytes

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this