Influence of encapsulated heat shock protein HSP70 on the basic functional properties of blood phagocytes

O. Yu Kochetkova; M. M. Yurinskaya; M. B. Evgen’ev; O. G. Zatsepina; L. I. Shabarchina; A. V. Suslikov; S. A. Tikhonenko; M. G. Vinokurov

doi:10.1134/S001249661506006X

Influence of encapsulated heat shock protein HSP70 on the basic functional properties of blood phagocytes

O. Yu Kochetkova, M. M. Yurinskaya, M. B. Evgen’ev, O. G. Zatsepina, L. I. Shabarchina, A. V. Suslikov, S. A. Tikhonenko, M. G. Vinokurov

Research output: Contribution to journal › Article › peer-review

Abstract

Microencapsulated heat shock proteins HSP 70 were studied in terms of their effects on neutrophil apoptosis, production of reactive oxygen species, and secretion of TNF-α by human neurtrophils and monocytes. Encapsulated HSP70 inhibited neutrophil apoptosis by 65% as compared to the effect of nonencapsulated HSP70; TNF-α production by the promonocytic THP-1 cells was similarly inhibited by the non-encapsulated and encapsulated HSP70. Thus, the polyelectrolyte micromolecules can be used as containers for effective delivery of HSP70 up to neutrophils and monocytes to correct the innate immunity functions.

Original language	English
Pages (from-to)	299-302
Number of pages	4
Journal	Doklady Biological Sciences
Volume	465
Issue number	1
DOIs	https://doi.org/10.1134/S001249661506006X
State	Published - 1 Nov 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015, Pleiades Publishing, Ltd.

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
General Agricultural and Biological Sciences

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10.1134/S001249661506006X

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title = "Influence of encapsulated heat shock protein HSP70 on the basic functional properties of blood phagocytes",

abstract = "Microencapsulated heat shock proteins HSP 70 were studied in terms of their effects on neutrophil apoptosis, production of reactive oxygen species, and secretion of TNF-α by human neurtrophils and monocytes. Encapsulated HSP70 inhibited neutrophil apoptosis by 65% as compared to the effect of nonencapsulated HSP70; TNF-α production by the promonocytic THP-1 cells was similarly inhibited by the non-encapsulated and encapsulated HSP70. Thus, the polyelectrolyte micromolecules can be used as containers for effective delivery of HSP70 up to neutrophils and monocytes to correct the innate immunity functions.",

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doi = "10.1134/S001249661506006X",

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AU - Kochetkova, O. Yu

AU - Yurinskaya, M. M.

AU - Evgen’ev, M. B.

AU - Zatsepina, O. G.

AU - Shabarchina, L. I.

AU - Suslikov, A. V.

AU - Tikhonenko, S. A.

AU - Vinokurov, M. G.

PY - 2015/11/1

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AB - Microencapsulated heat shock proteins HSP 70 were studied in terms of their effects on neutrophil apoptosis, production of reactive oxygen species, and secretion of TNF-α by human neurtrophils and monocytes. Encapsulated HSP70 inhibited neutrophil apoptosis by 65% as compared to the effect of nonencapsulated HSP70; TNF-α production by the promonocytic THP-1 cells was similarly inhibited by the non-encapsulated and encapsulated HSP70. Thus, the polyelectrolyte micromolecules can be used as containers for effective delivery of HSP70 up to neutrophils and monocytes to correct the innate immunity functions.

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Influence of encapsulated heat shock protein HSP70 on the basic functional properties of blood phagocytes

Abstract

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ASJC Scopus subject areas

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