Influence of 17β-estradiol and progesterone on rat ocular lens

J. Scharf; N. Azzam; D. Schapira; A. Dovrat; D. Gershon; M. Silbermann

doi:10.1159/000267705

Influence of 17β-estradiol and progesterone on rat ocular lens

J. Scharf, N. Azzam, D. Schapira, A. Dovrat, D. Gershon, M. Silbermann

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of 17β-estradiol and progesterone on ocular lens in rats and untreated controls was studied. In the treated lenses, the activity of hexokinase and glucose-6-phosphate dehydrogenase remained unchanged. The activity of aldolase was increased in 18- and 20-month-old lenses as compared to controls. Aldose reductase activity was decreased at the age of 20 months (p < 0.001). Structural lens proteins studies by SDS polyacrylamide gel electrophoresis and immunodecoration with specific antibodies for crystallines αA + αB and β + γ suggest some protective effect in treated animals.

Original language	English
Pages (from-to)	197-201
Number of pages	5
Journal	Ophthalmic Research
Volume	27
Issue number	4
DOIs	https://doi.org/10.1159/000267705
State	Published - 1995
Externally published	Yes

Keywords

Estrogen
Lens enzymes
Lens proteins
Progesterone
Rat lenses

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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10.1159/000267705

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abstract = "The effect of 17β-estradiol and progesterone on ocular lens in rats and untreated controls was studied. In the treated lenses, the activity of hexokinase and glucose-6-phosphate dehydrogenase remained unchanged. The activity of aldolase was increased in 18- and 20-month-old lenses as compared to controls. Aldose reductase activity was decreased at the age of 20 months (p < 0.001). Structural lens proteins studies by SDS polyacrylamide gel electrophoresis and immunodecoration with specific antibodies for crystallines αA + αB and β + γ suggest some protective effect in treated animals.",

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author = "J. Scharf and N. Azzam and D. Schapira and A. Dovrat and D. Gershon and M. Silbermann",

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AU - Azzam, N.

AU - Schapira, D.

AU - Dovrat, A.

AU - Gershon, D.

AU - Silbermann, M.

PY - 1995

Y1 - 1995

N2 - The effect of 17β-estradiol and progesterone on ocular lens in rats and untreated controls was studied. In the treated lenses, the activity of hexokinase and glucose-6-phosphate dehydrogenase remained unchanged. The activity of aldolase was increased in 18- and 20-month-old lenses as compared to controls. Aldose reductase activity was decreased at the age of 20 months (p < 0.001). Structural lens proteins studies by SDS polyacrylamide gel electrophoresis and immunodecoration with specific antibodies for crystallines αA + αB and β + γ suggest some protective effect in treated animals.

AB - The effect of 17β-estradiol and progesterone on ocular lens in rats and untreated controls was studied. In the treated lenses, the activity of hexokinase and glucose-6-phosphate dehydrogenase remained unchanged. The activity of aldolase was increased in 18- and 20-month-old lenses as compared to controls. Aldose reductase activity was decreased at the age of 20 months (p < 0.001). Structural lens proteins studies by SDS polyacrylamide gel electrophoresis and immunodecoration with specific antibodies for crystallines αA + αB and β + γ suggest some protective effect in treated animals.

KW - Estrogen

KW - Lens enzymes

KW - Lens proteins

KW - Progesterone

KW - Rat lenses

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Influence of 17β-estradiol and progesterone on rat ocular lens

Abstract

Keywords

ASJC Scopus subject areas

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