Influence of 17β-estradiol and progesterone on rat ocular lens

J. Scharf, N. Azzam, D. Schapira, A. Dovrat, D. Gershon, M. Silbermann

Research output: Contribution to journalArticlepeer-review


The effect of 17β-estradiol and progesterone on ocular lens in rats and untreated controls was studied. In the treated lenses, the activity of hexokinase and glucose-6-phosphate dehydrogenase remained unchanged. The activity of aldolase was increased in 18- and 20-month-old lenses as compared to controls. Aldose reductase activity was decreased at the age of 20 months (p < 0.001). Structural lens proteins studies by SDS polyacrylamide gel electrophoresis and immunodecoration with specific antibodies for crystallines αA + αB and β + γ suggest some protective effect in treated animals.

Original languageEnglish
Pages (from-to)197-201
Number of pages5
JournalOphthalmic Research
Issue number4
StatePublished - 1995
Externally publishedYes


  • Estrogen
  • Lens enzymes
  • Lens proteins
  • Progesterone
  • Rat lenses

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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