We aimed to examine the effects of infertility treatments on the risk of Autism Spectrum Disorder (ASD). Data were from a representative national registry on 110,093 male live births in Israel (born: 1999–2008; and ASD: 975, 0.9%). Infertility treatments included In Vitro Fertilization (IVF), and five hormone treatments. Relative risk (RR) was estimated with multivariable logistic models. Results showed that IVF treatment compared with spontaneous conception was not statistically significantly associated with the risk of ASD. Only progesterone hormone treatment was associated with a statistically significant (p <.05) increased risk of ASD (RR = 1.51, 95% CI 1.22, 1.86) compared to the group with no progesterone treatment. In conclusion, progesterone exposure during the critical period of fetal life elevated the risk of ASD, possibly reflecting epigenetic modification.
|Number of pages||5|
|Journal||Progress in Neuro-Psychopharmacology and Biological Psychiatry|
|State||Published - 30 Aug 2018|
Bibliographical noteFunding Information:
This study was supported by Maccabi Healthcare research grant 45777 to author Levine at the University of Haifa , and in part by the Seaver Foundation ; Sven Sandin, PhD, is a Seaver Faculty Scholar.
Levine has received research support, and/or consultancy fees and/or travel support from Shire, F. Hoffmann-La Roche and Eli Lilly, which are all unrelated to this research. Shalev and Chodick were funded by Maccabi Institute for Research and Innovation, Maccabi Healthcare Services, Tel Aviv Israel. Authors Davidovitch, Chodick, Shalev, Eisenberg and Dan are employees of Maccabi Healthcare Service. The remaining authors declare no conflict of interest.
This study was supported by Maccabi Healthcare research grant 45777 to author Levine at the University of Haifa, and in part by the Seaver Foundation; Sven Sandin, PhD, is a Seaver Faculty Scholar.
© 2018 Elsevier Inc.
- Autism Spectrum disorders
ASJC Scopus subject areas
- Biological Psychiatry