TY - JOUR
T1 - Infection with Kaposi's sarcoma-associated herpesvirus among families of patients with Classic Kaposi's sarcoma
AU - Guttman-Yassky, Emma
AU - Kra-Oz, Zippi
AU - Dubnov, Jonathan
AU - Friedman-Birnbaum, Rachel
AU - Segal, Isic
AU - Zaltzman, Neli
AU - Roth, Tova
AU - Schwartz, Fidi
AU - Linn, Shai
AU - Rozenman, Dganit
AU - David, Michael
AU - Silbermann, Michael
AU - Barchana, Micha
AU - Bergman, Reuven
AU - Sarid, Ronit
PY - 2005/11
Y1 - 2005/11
N2 - Background: Classic Kaposi's sarcoma (CKS) primarily affects elderly Mediterranean or Eastern European men. Incidence rates of CKS in Israel are among the world's highest. In practically all cases, antibodies against Kaposi's sarcoma-associated herpesvirus (KSHV) can be detected. A relatively high seroprevalence rate of KSHV in Israel generally correlates with the incidence of CKS. A sexual mode of virus transmission is recognized among homosexual men, whereas the precise transmission routes in the heterosexual population and those with CKS are still unclear. Objective: To better assess the transmission routes of KSHV in Israeli patients with CKS and their first-degree relatives as compared with a control group. Design: Serum was collected from all study participants and tested for KSHV antibodies by means of latent and lytic immunofluorescence assays. An open reading frame 65 (ORF65) Western blot assay was applied as a confirmatory tool. Setting: Three dermatological departments in Israel. Patients: Sixty-four Jewish patients with CKS, 143 of their first-degree relatives, and 186 hospital-based control subjects. Results: Seropositivity to KSHV was detected in 62 (96.9%) of the patients with CKS, in 56 (39.2%) of their first-degree relatives, and in only 21 (11.3%) of the hospital controls (P<.001). The specific relationship with the index patient (spouse, offspring, or sibling) had no significant effect on the prevalence of serpositivity in the family members. Conclusion: Our serologic evidence of familial clustering of KSHV infection suggests a predominantly nonsexual horizontal transmission route of the virus.
AB - Background: Classic Kaposi's sarcoma (CKS) primarily affects elderly Mediterranean or Eastern European men. Incidence rates of CKS in Israel are among the world's highest. In practically all cases, antibodies against Kaposi's sarcoma-associated herpesvirus (KSHV) can be detected. A relatively high seroprevalence rate of KSHV in Israel generally correlates with the incidence of CKS. A sexual mode of virus transmission is recognized among homosexual men, whereas the precise transmission routes in the heterosexual population and those with CKS are still unclear. Objective: To better assess the transmission routes of KSHV in Israeli patients with CKS and their first-degree relatives as compared with a control group. Design: Serum was collected from all study participants and tested for KSHV antibodies by means of latent and lytic immunofluorescence assays. An open reading frame 65 (ORF65) Western blot assay was applied as a confirmatory tool. Setting: Three dermatological departments in Israel. Patients: Sixty-four Jewish patients with CKS, 143 of their first-degree relatives, and 186 hospital-based control subjects. Results: Seropositivity to KSHV was detected in 62 (96.9%) of the patients with CKS, in 56 (39.2%) of their first-degree relatives, and in only 21 (11.3%) of the hospital controls (P<.001). The specific relationship with the index patient (spouse, offspring, or sibling) had no significant effect on the prevalence of serpositivity in the family members. Conclusion: Our serologic evidence of familial clustering of KSHV infection suggests a predominantly nonsexual horizontal transmission route of the virus.
UR - http://www.scopus.com/inward/record.url?scp=27944511119&partnerID=8YFLogxK
U2 - 10.1001/archderm.141.11.1429
DO - 10.1001/archderm.141.11.1429
M3 - Article
C2 - 16301390
AN - SCOPUS:27944511119
SN - 0003-987X
VL - 141
SP - 1429
EP - 1434
JO - Archives of Dermatology
JF - Archives of Dermatology
IS - 11
ER -