Independent localization of MAP2, CaMKIIα and β-actin RNAs in low copy numbers

Martin Mikl, Georgia Vendra, Michael A. Kiebler

Research output: Contribution to journalArticlepeer-review

Abstract

Messenger RNA localization involves the assembly of ribonucleoprotein particles (RNPs) and their subsequent transport along the cytoskeleton to their final destination. Here, we provide new evidence that microtubule-associated protein 2 (MAP2), calcium/calmodulin-dependent protein kinase II (CaMKIIα) and β-actin RNAs localize to dendrites in distinct RNPs, which contain-unexpectedly-very few RNA molecules. The number of MAP2 molecules per particle is affected by synaptic activity and Staufen 2, indicating that RNP composition is tightly controlled. Our data suggest that the independent localization of individual RNAs in low copy numbers could contribute to tighter temporal and spatial control of expression in neurons and synapse-specific plasticity.

Original languageEnglish
Pages (from-to)1077-1084
Number of pages8
JournalEMBO Reports
Volume12
Issue number10
DOIs
StatePublished - Oct 2011
Externally publishedYes

Keywords

  • CaMKIIa
  • MAP2 mRNA
  • RNA localization
  • Staufen 2
  • β-actin

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Biochemistry

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