Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load

Zealand University Hospital; Sydvestjysk Sygehus; The Danish Covid-19 Genome Consortium; AAU Coordination; AAU Laboratory; AAU Bioinformatics; AAU CLAUDIA/IT; AAU Legal and Admin; AAU SUND; AAU Computer Science; Statens Serum Institut; Aalborg University Hospital; Rigshospitalet; Hvidovre Hospital; Aarhus University Hospital; Odense University Hospital; Herlev Hospital; Sygehus Lillebælt

doi:10.1038/s41467-021-27202-x

Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load

Zealand University Hospital, Sydvestjysk Sygehus, The Danish Covid-19 Genome Consortium, AAU Coordination, AAU Laboratory, AAU Bioinformatics, AAU CLAUDIA/IT, AAU Legal and Admin, AAU SUND, AAU Computer Science, Statens Serum Institut, Aalborg University Hospital, Rigshospitalet, Hvidovre Hospital, Aarhus University Hospital, Odense University Hospital, Herlev Hospital, Sygehus Lillebælt

Research output: Contribution to journal › Article › peer-review

Abstract

New lineages of SARS-CoV-2 are of potential concern due to higher transmissibility, risk of severe outcomes, and/or escape from neutralizing antibodies. Lineage B.1.1.7 (the Alpha variant) became dominant in early 2021, but the association between transmissibility and risk factors, such as age of primary case and viral load remains poorly understood. Here, we used comprehensive administrative data from Denmark, comprising the full population (January 11 to February 7, 2021), to estimate household transmissibility. This study included 5,241 households with primary cases; 808 were infected with lineage B.1.1.7 and 4,433 with other lineages. Here, we report an attack rate of 38% in households with a primary case infected with B.1.1.7 and 27% in households with other lineages. Primary cases infected with B.1.1.7 had an increased transmissibility of 1.5–1.7 times that of primary cases infected with other lineages. The increased transmissibility of B.1.1.7 was multiplicative across age and viral load.

Original language	English
Article number	7251
Journal	Nature Communications
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41467-021-27202-x
State	Published - 13 Dec 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021, The Author(s).

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41467-021-27202-x

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Zealand University Hospital, Sydvestjysk Sygehus, The Danish Covid-19 Genome Consortium, AAU Coordination, AAU Laboratory, AAU Bioinformatics, AAU CLAUDIA/IT, AAU Legal and Admin, AAU SUND, AAU Computer Science, Statens Serum Institut, Aalborg University Hospital, Rigshospitalet, Hvidovre Hospital, Aarhus University Hospital, Odense University Hospital, Herlev Hospital, & Sygehus Lillebælt (2021). Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load. Nature Communications, 12(1), Article 7251. https://doi.org/10.1038/s41467-021-27202-x

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title = "Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load",

abstract = "New lineages of SARS-CoV-2 are of potential concern due to higher transmissibility, risk of severe outcomes, and/or escape from neutralizing antibodies. Lineage B.1.1.7 (the Alpha variant) became dominant in early 2021, but the association between transmissibility and risk factors, such as age of primary case and viral load remains poorly understood. Here, we used comprehensive administrative data from Denmark, comprising the full population (January 11 to February 7, 2021), to estimate household transmissibility. This study included 5,241 households with primary cases; 808 were infected with lineage B.1.1.7 and 4,433 with other lineages. Here, we report an attack rate of 38% in households with a primary case infected with B.1.1.7 and 27% in households with other lineages. Primary cases infected with B.1.1.7 had an increased transmissibility of 1.5–1.7 times that of primary cases infected with other lineages. The increased transmissibility of B.1.1.7 was multiplicative across age and viral load.",

author = "{Zealand University Hospital} and {Sydvestjysk Sygehus} and {The Danish Covid-19 Genome Consortium} and {AAU Coordination} and {AAU Laboratory} and {AAU Bioinformatics} and {AAU CLAUDIA/IT} and {AAU Legal and Admin} and {AAU SUND} and {AAU Computer Science} and {Statens Serum Institut} and {Aalborg University Hospital} and Rigshospitalet and {Hvidovre Hospital} and {Aarhus University Hospital} and {Odense University Hospital} and {Herlev Hospital} and {Sygehus Lilleb{\ae}lt} and Lyngse, {Frederik Plesner} and K{\aa}re M{\o}lbak and Skov, {Robert Leo} and Christiansen, {Lasse Engbo} and Mortensen, {Laust Hvas} and Mads Albertsen and M{\o}ller, {Camilla Holten} and Krause, {Tyra Grove} and Morten Rasmussen and Michaelsen, {Thomas Yssing} and Marianne Voldstedlund and Jannik Fonager and Nina Steenhard and Jakob Brandt and Simon Knuttson and S{\o}rensen, {Emil A.} and Jensen, {Thomas B.N.} and Trine S{\o}rensen and Celine Petersen and Clarisse Chiche-Lapierre and Hansen, {Frederik T.} and Collados, {Emilio F.} and Amalie Berg and Bielidt, {Susanne R.} and Dall, {Sebastian M.} and Erika Dvarionaite and Hansen, {Susan H.} and J{\o}rgensen, {Vibeke R.} and Nicolajsen, {Trine B.} and Wagma Saei and {\O}stergaard, {Stine K.} and Michaelsen, {Thomas Y.} and Vang Le-Quy and Mantas Sereika and Kirkegaard, {Rasmus H.} and Andersen, {Kasper S.} and Andersen, {Martin H.} and Hansen, {Karsten K.} and Mads Boye and Bach, {Mads P.} and Peter Dissing and Anton Drastrup-Fjordbak and Michael Collin and Finn B{\"u}ttner and Susanne Andersen and Otte, {Lea Sass} and Martin B{\o}gsted and Rasmus Br{\o}ndum and Katja Hose and Tomer Sagi",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = dec,

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doi = "10.1038/s41467-021-27202-x",

language = "English",

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Zealand University Hospital, Sydvestjysk Sygehus, The Danish Covid-19 Genome Consortium, AAU Coordination, AAU Laboratory, AAU Bioinformatics, AAU CLAUDIA/IT, AAU Legal and Admin, AAU SUND, AAU Computer Science, Statens Serum Institut, Aalborg University Hospital, Rigshospitalet, Hvidovre Hospital, Aarhus University Hospital, Odense University Hospital, Herlev Hospital & Sygehus Lillebælt 2021, 'Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load', Nature Communications, vol. 12, no. 1, 7251. https://doi.org/10.1038/s41467-021-27202-x

TY - JOUR

T1 - Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load

AU - Zealand University Hospital

AU - Sydvestjysk Sygehus

AU - The Danish Covid-19 Genome Consortium

AU - AAU Coordination

AU - AAU Laboratory

AU - AAU Bioinformatics

AU - AAU CLAUDIA/IT

AU - AAU Legal and Admin

AU - AAU SUND

AU - AAU Computer Science

AU - Statens Serum Institut

AU - Aalborg University Hospital

AU - Rigshospitalet

AU - Hvidovre Hospital

AU - Aarhus University Hospital

AU - Odense University Hospital

AU - Herlev Hospital

AU - Sygehus Lillebælt

AU - Lyngse, Frederik Plesner

AU - Mølbak, Kåre

AU - Skov, Robert Leo

AU - Christiansen, Lasse Engbo

AU - Mortensen, Laust Hvas

AU - Albertsen, Mads

AU - Møller, Camilla Holten

AU - Krause, Tyra Grove

AU - Rasmussen, Morten

AU - Michaelsen, Thomas Yssing

AU - Voldstedlund, Marianne

AU - Fonager, Jannik

AU - Steenhard, Nina

AU - Brandt, Jakob

AU - Knuttson, Simon

AU - Sørensen, Emil A.

AU - Jensen, Thomas B.N.

AU - Sørensen, Trine

AU - Petersen, Celine

AU - Chiche-Lapierre, Clarisse

AU - Hansen, Frederik T.

AU - Collados, Emilio F.

AU - Berg, Amalie

AU - Bielidt, Susanne R.

AU - Dall, Sebastian M.

AU - Dvarionaite, Erika

AU - Hansen, Susan H.

AU - Jørgensen, Vibeke R.

AU - Nicolajsen, Trine B.

AU - Saei, Wagma

AU - Østergaard, Stine K.

AU - Michaelsen, Thomas Y.

AU - Le-Quy, Vang

AU - Sereika, Mantas

AU - Kirkegaard, Rasmus H.

AU - Andersen, Kasper S.

AU - Andersen, Martin H.

AU - Hansen, Karsten K.

AU - Boye, Mads

AU - Bach, Mads P.

AU - Dissing, Peter

AU - Drastrup-Fjordbak, Anton

AU - Collin, Michael

AU - Büttner, Finn

AU - Andersen, Susanne

AU - Otte, Lea Sass

AU - Bøgsted, Martin

AU - Brøndum, Rasmus

AU - Hose, Katja

AU - Sagi, Tomer

PY - 2021/12/13

Y1 - 2021/12/13

N2 - New lineages of SARS-CoV-2 are of potential concern due to higher transmissibility, risk of severe outcomes, and/or escape from neutralizing antibodies. Lineage B.1.1.7 (the Alpha variant) became dominant in early 2021, but the association between transmissibility and risk factors, such as age of primary case and viral load remains poorly understood. Here, we used comprehensive administrative data from Denmark, comprising the full population (January 11 to February 7, 2021), to estimate household transmissibility. This study included 5,241 households with primary cases; 808 were infected with lineage B.1.1.7 and 4,433 with other lineages. Here, we report an attack rate of 38% in households with a primary case infected with B.1.1.7 and 27% in households with other lineages. Primary cases infected with B.1.1.7 had an increased transmissibility of 1.5–1.7 times that of primary cases infected with other lineages. The increased transmissibility of B.1.1.7 was multiplicative across age and viral load.

AB - New lineages of SARS-CoV-2 are of potential concern due to higher transmissibility, risk of severe outcomes, and/or escape from neutralizing antibodies. Lineage B.1.1.7 (the Alpha variant) became dominant in early 2021, but the association between transmissibility and risk factors, such as age of primary case and viral load remains poorly understood. Here, we used comprehensive administrative data from Denmark, comprising the full population (January 11 to February 7, 2021), to estimate household transmissibility. This study included 5,241 households with primary cases; 808 were infected with lineage B.1.1.7 and 4,433 with other lineages. Here, we report an attack rate of 38% in households with a primary case infected with B.1.1.7 and 27% in households with other lineages. Primary cases infected with B.1.1.7 had an increased transmissibility of 1.5–1.7 times that of primary cases infected with other lineages. The increased transmissibility of B.1.1.7 was multiplicative across age and viral load.

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U2 - 10.1038/s41467-021-27202-x

DO - 10.1038/s41467-021-27202-x

M3 - Article

C2 - 34903718

AN - SCOPUS:85122774462

SN - 2041-1723

VL - 12

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 7251

ER -

Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

Access to Document

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