TY - JOUR
T1 - Incidence and survival characteristics of diseases among holocaust survivors that have immigrated to Israel
T2 - Abstracts of the 4th World Congress on Developmental Origins of Health and Disease (DOHaD), 13–16 September 2006, Educatorium, University of Utrecht, The Netherlands
AU - Vin-Raviv, Neomi
AU - Liphshitz, Irena
AU - Linn, Shai
AU - Keinan-Boker, Lital
AU - Barchana, Micha
PY - 2006/8/12
Y1 - 2006/8/12
N2 - Background: Israelis of European and American origin exhibit high cancer morbidity. Many of them were extensively exposed to severe conditions during World War II (WWII) in Europe. Former studies in non-Jewish Dutch subjects, exposed to extreme famine during WWII, disclosed higher risk of breast and prostate cancer. Aim: to assess cancer incidence and survival in Jewish holocaust survivors. Methods: A prospective historical cohort based on Jews born in Europe who immigrated to Israel before (non-exposed) and after (exposed) WWII. Cancer morbidity and survival data were obtained through linkage with the National Cancer Registry and the Central Bureau of Statistics, respectively. Standardized incidence Ratios (SIRs) and 95% confidence intervals (95% CI) were calculated for total and specific cancer sites. Results: The exposed and non-exposed groups contributed 4,011,264 and 908,436 person-years of follow-up, with 45,206 and 10,282 cancer cases, respectively. SIRs for all cancer sites in the exposed group ranged 1.14 to 3.42 and were statistically significant in both genders. Highest risks were observed in the youngest birth cohort: SIR (95% CI) were 3.42 (3.23, 3.61) and 2.32 (2.22, 2.41) for males and females born in 1940—1945, respectively. This pattern was especially pronounced for breast and colorectal cancer. Five years survival rates were lower in the exposed vs. the nonexposed by 5—13%, and holocaust survivors were often diagnosed at more advanced disease stages. Conclusions: Holocaust survivors present higher cancer incidence, especially breast and colon cancer, and lower survival rates compared to immigrants not exposed to WWII. Those exposed at younger ages were mostly affected. Disclosure: Was this work supported by industry? No.
AB - Background: Israelis of European and American origin exhibit high cancer morbidity. Many of them were extensively exposed to severe conditions during World War II (WWII) in Europe. Former studies in non-Jewish Dutch subjects, exposed to extreme famine during WWII, disclosed higher risk of breast and prostate cancer. Aim: to assess cancer incidence and survival in Jewish holocaust survivors. Methods: A prospective historical cohort based on Jews born in Europe who immigrated to Israel before (non-exposed) and after (exposed) WWII. Cancer morbidity and survival data were obtained through linkage with the National Cancer Registry and the Central Bureau of Statistics, respectively. Standardized incidence Ratios (SIRs) and 95% confidence intervals (95% CI) were calculated for total and specific cancer sites. Results: The exposed and non-exposed groups contributed 4,011,264 and 908,436 person-years of follow-up, with 45,206 and 10,282 cancer cases, respectively. SIRs for all cancer sites in the exposed group ranged 1.14 to 3.42 and were statistically significant in both genders. Highest risks were observed in the youngest birth cohort: SIR (95% CI) were 3.42 (3.23, 3.61) and 2.32 (2.22, 2.41) for males and females born in 1940—1945, respectively. This pattern was especially pronounced for breast and colorectal cancer. Five years survival rates were lower in the exposed vs. the nonexposed by 5—13%, and holocaust survivors were often diagnosed at more advanced disease stages. Conclusions: Holocaust survivors present higher cancer incidence, especially breast and colon cancer, and lower survival rates compared to immigrants not exposed to WWII. Those exposed at younger ages were mostly affected. Disclosure: Was this work supported by industry? No.
U2 - 10.1016/j.earlhumdev.2006.06.003
DO - 10.1016/j.earlhumdev.2006.06.003
M3 - Meeting Abstract
SN - 0378-3782
VL - 82
SP - 532
JO - Early Human Development
JF - Early Human Development
IS - 8
ER -