In vivo optogenetic identification and manipulation of GABAergic interneuron subtypes

Lisa Roux, Eran Stark, Lucas Sjulson, György Buzsáki

Research output: Contribution to journalReview articlepeer-review


Identification and manipulation of different GABAergic interneuron classes in the behaving animal are important to understand their role in circuit dynamics and behavior. The combination of optogenetics and large-scale neuronal recordings allows specific interneuron populations to be identified and perturbed for circuit analysis in intact animals. A crucial aspect of this approach is coupling electrophysiological recording with spatially and temporally precise light delivery. Focal multisite illumination of neuronal activators and silencers in predetermined temporal configurations or a closed loop manner opens the door to addressing many novel questions. Recent progress demonstrates the utility and power of this novel technique for interneuron research.

Original languageEnglish
Pages (from-to)88-95
Number of pages8
JournalCurrent Opinion in Neurobiology
StatePublished - Jun 2014
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience (all)


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