The effect of pregnancy and lactation on GABA(A) receptor and central- and peripheral-type benzodiazepine receptors (CBR and PBR, respectively) was studied in female Sprague-Dawley rats. Pregnancy was associated with increased CBR density (on day 19) in the hippocampus and with decreased [3H]Ro 15-1788-specific binding in the hypothalamus during pregnancy and lactation. A similar decrease in [3H]PK 11195-speciric binding was observed in the hypothalamus and pituitary. An increase in PBR density in the ovary and uterus was observed during pregnancy, while adrenal PBR density was down-regulated during pregnancy and lactation. It seems that the hormonal changes occurring during pregnancy and lactation play a role in the regulation of CBR and PBR in discrete tissues.
Bibliographical noteFunding Information:
This study was supportedin part by Grant 91-00146(t o M.G. and S.H.S.) from the U.S.-Israel BinationalS cience Foundation.W e thank Miss Ruth Singer for typing and editing lhz manuscript.
- GABA(A) receptor
- central-type benzodiazepine receptor
- peripheral-type benzodiazepine receptor
ASJC Scopus subject areas
- Neuroscience (all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology