Immunoglobulin‐like domain is present in the extracellular part of the receptor tyrosine kinase from the marine sponge geodia cydonium

Heike Schäcke, Baruch Rinkevich, Vera Gamulin, Isabel M. Müller, Werner E.G. Müller

Research output: Contribution to journalArticlepeer-review

Abstract

We have isolated and characterized two cDNAs from the marine sponge Geodia cydonium coding for a new member of a receptor tyrosine kinase of class II. The deduced amino acid sequence shows two characteristic domains: (i) the tyrosine kinase domain; and (ii) and immunoglobulin‐like domain. The latter part shows high homology to the vertebrate C2 type immunoglobulin domain. This result demonstrates that immunoglobulin domains are not recent achievements of higher animals but exist also in those animals which have diverged from other organisms about 800 million years ago.

Original languageEnglish
Pages (from-to)273-276
Number of pages4
JournalJournal of Molecular Recognition
Volume7
Issue number4
DOIs
StatePublished - Dec 1994
Externally publishedYes

Keywords

  • Geodia cydonium
  • Immunoglobulin‐like domain
  • Phylogeny
  • Sponges
  • Tyrosine kinase receptor

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

Fingerprint

Dive into the research topics of 'Immunoglobulin‐like domain is present in the extracellular part of the receptor tyrosine kinase from the marine sponge geodia cydonium'. Together they form a unique fingerprint.

Cite this