Identifying appropriate candidates for long-acting antiretroviral therapy: findings from a survey of health care providers in the ATLAS-2M trial

Miranda Murray, Deanna Kerrigan, Krischan J. Hudson, Nicola Walters, Tahilin Sanchez Karver, Andrea Mantsios, Noya Galai

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Recent results from Phase 3 clinical trials with cabotegravir (CAB) and rilpivirine (RPV) long-acting (LA) have shown that a monthly regimen is non-inferior to daily oral antiretroviral therapy (ART). Additional insights are necessary to prepare for LA ART roll-out, including identifying the appropriate patients. Methods: Within the ATLAS-2M trial, an online survey was administered to 329 health care providers (HCPs) in 13 countries. Multivariate logistic regression was conducted to identify factors associated with providers considering a greater proportion of patients as appropriate LA ART candidates. Results: Forty-seven percent of HCPs believed that “some” patients (25–50%) would be appropriate while nearly one-quarter of HCPs (23%) felt that “many” patients (more than 50%) would be appropriate candidates for LA ART. Providers in the African region had a greater odds of identifying a greater proportion of their patients as appropriate candidates (AOR 8.97; p < 0.001) vs. other regions. Nurses/physician assistants and research staff/pharmacists had a higher odds of perceiving a greater proportion of their patients as appropriate candidates vs. physicians, respectively (AOR 3.42 p < 0.001; AOR 2.48; p = 0.19). Providers who had experience transitioning patients from LA to oral ART had a higher odds of reporting that more of their patients would be appropriate candidates (AOR 1.64; p = 0.008) vs. those without experience. Conclusion: A significant proportion of providers reported that many of their patients would be appropriate candidates for LA ART. To optimize roll-out after regulatory approval, it is important to support providers with tools to help identify patients who would most benefit from this option.

Original languageEnglish
Pages (from-to)105-113
Number of pages9
JournalHIV Research and Clinical Practice
Volume21
Issue number4
DOIs
StatePublished - 11 Oct 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 ViiV Healthcare. Published by Informa UK Limited, trading as Taylor & Francis Group.

Keywords

  • HIV
  • clinical trial
  • long-acting
  • survey

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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