HK/LK polymorphism and its genetic determination in speke's gazelle

N. Georgiadis, P. Dunham, B. Read, A. Templeton

Research output: Contribution to journalArticlepeer-review


Concentrations of potassium (K) and sodium (Na) were determined in the erythrocytes of 28 members of an interbreeding herd of Speke's gazelle. The distribution of K concentrations and Na/K concentration ratios suggested the presence of the high-K/low-K (HK/LK) polymorphism known in erythrocytes of domestic bovids. The pedigree of the herd of gazelles is known completely, permitting examination of the inheritance of HK/LK polymorphism by overlaying the distribution of phenotypes on the pedigree. Statistical analyses clearly Indicate a strong genetic component in the phenotypic variability that is entirely consistent with a single autosomal locus, two-allele mode of inheritance, with the LK allele being dominant. This is the first demonstration of HK/LK polymorphism in a wild bovid species. The evidence indicates that HK/LK polymorphism is of considerable evolutionary age, is of monophyletic origin, and is maintained by selection.

Original languageEnglish
Pages (from-to)325-331
Number of pages7
JournalJournal of Heredity
Issue number5
StatePublished - 1988
Externally publishedYes

Bibliographical note

Funding Information:
From the Department of Biology, Syracuse University, New York (Georgiadis and Dunham), the St Louis Zoological Park, Missouri (Read), and the Department ol Biology, Washington University, St Louis, Missouri (Templeton). Dr. Georgiadis is currently at the Serengeti Research Institute, Seronera, Tanzania. The work was supported by grants from the National Institutes of Health (GM31571 to AT and DK28290 and DK33640 to PD). The authors thank Dr. David T. Sullivan of Syracuse University for a critical reading of the manuscript Address reprint requests to Dr. Dunham, Department of Biology, Syracuse University, Syracuse, NY 132+4.

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Genetics
  • Genetics(clinical)


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