Hippocampal plasticity involves extensive gene induction and multiple cellular mechanisms

Dana Hevroni, Amir Rattner, Marsha Bundman, Doron Lederfein, Awni Gabarah, Miriam Mangelus, Michael A. Silverman, Hilla Kedar, Cathy Naor, Masayo Kornuc, Tamar Hanoch, Rony Seger, Lars E. Theill, Elly Nedivi, Gal Richter-Levin, Yoav Citri

Research output: Contribution to journalArticlepeer-review


Long-term plasticity of the central nervous system (CNS) involves induction of a set of genes whose identity is incompletely characterized. To identify candidate plasticity-related genes (CPGs), we conducted an exhaustive screen for genes that undergo induction or downregulation in the hippocampus dentate gyrus (DG) following animal treatment with the potent glutamate analog, kainate. The screen yielded 362 upregulated CPGs and 41 downregulated transcripts (dCPGs) of these, 66 CPGs and 5 dCPGs are known genes that encode for a variety of signal transduction proteins, transcription factors, and structural proteins. Seven novel CPGs predict the following putative functions: cpg2-a dystrophin-like cytoskeletal protein; cpg4-a heat-shock protein: cpg16-a protein kinase; cpg20-a transcription factor; cpg21-a dual-specificity MAP-kinase phosphatase; and cpg30 and cpg38- two new seven-transmembrane domain receptors. Experiments performed in vitro and with cultured hippocampal cells confirmed the ability of the cpg-21 product to inactivate the MAP-kinase. To test relevance to neural plasticity, 66 CPGs were tested for induction by stimuli producing long-term potentiation (LTP). Approximately one-fourth of the genes examined were upregulated by LTP. These results indicate that an extensive genetic response is induced in mammalian brain after glutamate receptor activation, and imply that a significant proportion of this activity is coinduced by LTP. Based on the identified CPGs, it is conceivable that multiple cellular mechanisms underlie long-term plasticity of the nervous system.

Original languageEnglish
Pages (from-to)75-98
Number of pages24
JournalJournal of Molecular Neuroscience
Issue number2
StatePublished - 1998


  • Dentate gyrus
  • Gene expression
  • Glutamate
  • Hippocampus
  • Neural plasticity
  • Signal transduction
  • Synapse

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Hippocampal plasticity involves extensive gene induction and multiple cellular mechanisms'. Together they form a unique fingerprint.

Cite this