High CO2-bicarbonate buffer modifies GABAergic inhibitory effect at the crayfish neuromuscular synapse

Hava Golan, Edi Barkai, Yoram Grossman

Research output: Contribution to journalArticlepeer-review

Abstract

γ-Aminobutyric acid (GABA) activated channels have a considerable permeability to bicarbonate ions (HCO3-), which might alter the efficacy of chloride-dependent synaptic inhibition. Saturation of the bicarbonate-buffered physiologic solution with 15% CO2/85% O2 increased the depolarizing inhibitory postsynaptic potential (IPSP) amplitude in crayfish muscle by 290% due to a shift of +8.33 mV in its reversal potential. Consequently, the normal inhibition exerted by the IPSP on the excitatory postsynaptic potential is reversed to large excitation.

Original languageEnglish
Pages (from-to)149-152
Number of pages4
JournalBrain Research
Volume567
Issue number1
DOIs
StatePublished - 13 Dec 1991
Externally publishedYes

Keywords

  • Bicarbonate
  • Crayfish
  • Neuromuscular synapse
  • pCO
  • pH
  • γ-Aminobutyric acid inhibition

ASJC Scopus subject areas

  • Clinical Neurology
  • Molecular Biology
  • General Neuroscience
  • Developmental Biology

Fingerprint

Dive into the research topics of 'High CO2-bicarbonate buffer modifies GABAergic inhibitory effect at the crayfish neuromuscular synapse'. Together they form a unique fingerprint.

Cite this