High CO2-bicarbonate buffer modifies GABAergic inhibitory effect at the crayfish neuromuscular synapse

Hava Golan; Edi Barkai; Yoram Grossman

doi:10.1016/0006-8993(91)91448-A

High CO₂-bicarbonate buffer modifies GABAergic inhibitory effect at the crayfish neuromuscular synapse

Hava Golan, Edi Barkai, Yoram Grossman

Research output: Contribution to journal › Article › peer-review

Abstract

γ-Aminobutyric acid (GABA) activated channels have a considerable permeability to bicarbonate ions (HCO₃^-), which might alter the efficacy of chloride-dependent synaptic inhibition. Saturation of the bicarbonate-buffered physiologic solution with 15% CO₂/85% O₂ increased the depolarizing inhibitory postsynaptic potential (IPSP) amplitude in crayfish muscle by 290% due to a shift of +8.33 mV in its reversal potential. Consequently, the normal inhibition exerted by the IPSP on the excitatory postsynaptic potential is reversed to large excitation.

Original language	English
Pages (from-to)	149-152
Number of pages	4
Journal	Brain Research
Volume	567
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(91)91448-A
State	Published - 13 Dec 1991
Externally published	Yes

Keywords

Bicarbonate
Crayfish
Neuromuscular synapse
pCO
pH
γ-Aminobutyric acid inhibition

ASJC Scopus subject areas

Neuroscience (all)
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(91)91448-A

Cite this

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abstract = "γ-Aminobutyric acid (GABA) activated channels have a considerable permeability to bicarbonate ions (HCO3-), which might alter the efficacy of chloride-dependent synaptic inhibition. Saturation of the bicarbonate-buffered physiologic solution with 15% CO2/85% O2 increased the depolarizing inhibitory postsynaptic potential (IPSP) amplitude in crayfish muscle by 290% due to a shift of +8.33 mV in its reversal potential. Consequently, the normal inhibition exerted by the IPSP on the excitatory postsynaptic potential is reversed to large excitation.",

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AB - γ-Aminobutyric acid (GABA) activated channels have a considerable permeability to bicarbonate ions (HCO3-), which might alter the efficacy of chloride-dependent synaptic inhibition. Saturation of the bicarbonate-buffered physiologic solution with 15% CO2/85% O2 increased the depolarizing inhibitory postsynaptic potential (IPSP) amplitude in crayfish muscle by 290% due to a shift of +8.33 mV in its reversal potential. Consequently, the normal inhibition exerted by the IPSP on the excitatory postsynaptic potential is reversed to large excitation.

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