High but not low frequency stimulation of both the globus pallidus and the entopeduncular nucleus reduces 'compulsive' lever-pressing in rats

Oded Klavir; Christine Winter; Daphna Joel

doi:10.1016/j.bbr.2010.07.018

High but not low frequency stimulation of both the globus pallidus and the entopeduncular nucleus reduces 'compulsive' lever-pressing in rats

Oded Klavir, Christine Winter, Daphna Joel

Research output: Contribution to journal › Article › peer-review

Abstract

The anti-compulsive effects of high and low frequency stimulation (LFS, HFS) of the entopeduncular nucleus and globus pallidus (the rat's equivalent, respectively, of the primate's internal and external segments of the globus pallidus) were assessed in the signal attenuation rat model of obsessive-compulsive disorder (OCD). HFS, but not LFS, of the two nuclei exerted an anti-compulsive effect, suggesting that HFS of either segment of the globus pallidus may provide an additional therapeutic strategy for OCD.

Original language	English
Pages (from-to)	84-93
Number of pages	10
Journal	Behavioural Brain Research
Volume	216
Issue number	1
DOIs	https://doi.org/10.1016/j.bbr.2010.07.018
State	Published - 1 Jan 2011
Externally published	Yes

Keywords

Animal model
Deep brain stimulation (DBS)
Extinction
Obsessive-compulsive disorder (OCD)
Signal attenuation

ASJC Scopus subject areas

Behavioral Neuroscience

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10.1016/j.bbr.2010.07.018

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abstract = "The anti-compulsive effects of high and low frequency stimulation (LFS, HFS) of the entopeduncular nucleus and globus pallidus (the rat's equivalent, respectively, of the primate's internal and external segments of the globus pallidus) were assessed in the signal attenuation rat model of obsessive-compulsive disorder (OCD). HFS, but not LFS, of the two nuclei exerted an anti-compulsive effect, suggesting that HFS of either segment of the globus pallidus may provide an additional therapeutic strategy for OCD.",

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AU - Winter, Christine

AU - Joel, Daphna

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AB - The anti-compulsive effects of high and low frequency stimulation (LFS, HFS) of the entopeduncular nucleus and globus pallidus (the rat's equivalent, respectively, of the primate's internal and external segments of the globus pallidus) were assessed in the signal attenuation rat model of obsessive-compulsive disorder (OCD). HFS, but not LFS, of the two nuclei exerted an anti-compulsive effect, suggesting that HFS of either segment of the globus pallidus may provide an additional therapeutic strategy for OCD.

KW - Animal model

KW - Deep brain stimulation (DBS)

KW - Extinction

KW - Obsessive-compulsive disorder (OCD)

KW - Signal attenuation

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JO - Behavioural Brain Research

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ER -

High but not low frequency stimulation of both the globus pallidus and the entopeduncular nucleus reduces 'compulsive' lever-pressing in rats

Abstract

Keywords

ASJC Scopus subject areas

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