Diffusion tensor imaging detects reduction in diffusion anisotropy in acute and chronic white matter ischemic lesions. However, it is not clear weather this anisotropy reduction is due to damage to the white matter or structural changes in the tissue. In this work we have used high-b-value diffusion weighted imaging in order to study this issue. We have found that the slow diffusing component is isotropically increased in acute stroke areas, which might originates from increased tortuosity in the extra cellular space. Four weeks after stroke, the diffusion anisotropy at high-b-value approached control value while the low-b-value DTI was still reduced.
|Title of host publication
|Proceedings of the International Society for Magnetic Resonance in Medicine
|Number of pages
|Published - 2003