Hidradenitis suppurativa and schizophrenia: a nationwide cohort study

D. Tzur Bitan, D. Berzin, A. D. Cohen

Research output: Contribution to journalArticlepeer-review


Background: Hidradenitis suppurativa (HS) is a chronic, debilitating, dermatological disease that causes substantial psychosocial impediments with increased suicidal risk. Yet data on psychiatric comorbidity in HS have not been sufficiently elucidated in population-based studies. The current study sought to investigate the association between HS and schizophrenia, a major psychiatric disease, in a nationwide population-based study in Israel. Methods: Data mining was performed on the database of Clalit Health Services (CHS), the largest managed healthcare company in Israel. Patients diagnosed with HS (n = 4191) were examined and compared to age- and sex-matched controls (n = 20 941). The association between HS and schizophrenia was assessed via multivariate binary logistic regression, adjusting for demographic factors and smoking status. Results: The analysis revealed a tenfold increase in the prevalence of schizophrenia in HS patients compared to controls (1.4% and 0.4%, respectively, P < 0.001). In multivariate analysis, HS was found to be associated with schizophrenia (OR 1.44, 95% CI 1.01–2.07, P < 0.05). Conclusions: Hidradenitis suppurativa is associated with schizophrenia. Screening for severe mental illness during the assessment of patients with HS is of great importance, as comorbid psychiatric disorders may affect treatment outcomes.

Original languageEnglish
Pages (from-to)574-579
Number of pages6
JournalJournal of the European Academy of Dermatology and Venereology
Issue number3
StatePublished - 1 Mar 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 European Academy of Dermatology and Venereology


  • Adult
  • Cohort Studies
  • Cross-Sectional Studies
  • Female
  • Hidradenitis Suppurativa/complications
  • Humans
  • Israel
  • Male
  • Middle Aged
  • Retrospective Studies
  • Schizophrenia/complications


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