Hepatotoxicity of anti-inflammatory and analgesic drugs: Ultrastructural aspects

Irena Manov, Helen Motanis, Idan Frumin, Theodore Ciancu

Research output: Contribution to journalReview articlepeer-review


With the increasing incidence of drug-induced liver disease, attempts are being made to better understand the mechanisms behind these frequently life-endangering reactions. Analgesics and anti-inflammatory drugs are a major group exhibiting hepatotoxicity. We review research relating to these reactions, focusing on ultrastructural findings, which may contribute to the comprehension and possible avoidance of drug-induced liver disease. We also present some original observations on clinical material and cultured cells exposed to acetaminophen alone or in combination with the antioxidant N-acetylcysteine or the P-glycoprotein inhibitor verapamil.

Original languageEnglish
Pages (from-to)259-272
Number of pages14
JournalActa Pharmacologica Sinica
Issue number3
StatePublished - Mar 2006
Externally publishedYes


  • Acetaminophen
  • Acetylcysteine
  • Apoptosis
  • Aspirin
  • Cultured cells
  • Drug toxicity
  • Electron microscopy
  • Liver
  • Non-steroidal anti-inflammatory agents
  • P-glycoprotein

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology


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