Hemispheric integrative therapy in Landau-Kleffner syndrome: Applications for rehabilitation sciences

Victor M. Pedro, Gerry Leisman

Research output: Contribution to journalArticlepeer-review


A case study is presented of a 14-year-old right-handed Caucasian female diagnosed with the Landau-Kleffner Syndrome (LKS) at the age 31/2 years. Her LKS symptoms presented with abrupt disruption in language after normal development, electroencephalogram (EEG) brain-wave abnormality, seizure activity, inability to read, and impairment in her motor skills. After 11 years of pharmacological and special education interventions with no significant improvement in any measurable area of function, a multimodal approach using techniques purportedly aimed at facilitating inter-hemispheric communication was provided. At completion of the program, EEG was controlled, reading, language, and auditory processing improved and objective behavioral-social measures improved significantly.

Original languageEnglish
Pages (from-to)1227-1238
Number of pages12
JournalInternational Journal of Neuroscience
Issue number8
StatePublished - Aug 2005
Externally publishedYes

Bibliographical note

Funding Information:
Received 22 September 2004. This project was funded in part by a grant to G.L. from the Foundation for Cognitive Neuroscience, Interactive Metronome Corporation, and the Foundation for Allied Conservative Therapies Research. Address correspondence to Dr. Gerry Leisman, Carrick Institute for Clinical Ergonomics, Rehabilitation, and Applied Neuroscience, School of Engineering Technologies, State University of New York, College at Farmingdale, Lupton Hall, 2350 Broadhollow Road, Farmingdale, NY 11735-1021, USA. E-mail: leismag@farmingdale.edu


  • Hemispheric integration therapy
  • Landau-Kleffner syndrome

ASJC Scopus subject areas

  • Neuroscience (all)


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