Heat-shock protein HSP70 reduces the secretion of TNFα by neuroblastoma cells and human monocytes induced with beta-amyloid peptides

M. M. Yurinskaya; V. A. Mit’kevich; M. B. Evgen’ev; A. A. Makarov; M. G. Vinokurov

doi:10.1134/S0026893316060236

Heat-shock protein HSP70 reduces the secretion of TNFα by neuroblastoma cells and human monocytes induced with beta-amyloid peptides

M. M. Yurinskaya, V. A. Mit’kevich, M. B. Evgen’ev, A. A. Makarov, M. G. Vinokurov

Research output: Contribution to journal › Article › peer-review

Abstract

The progress of neurodegeneration in Alzheimer’s disease is closely associated with inflammatory processes in the brain tissues induced by beta-amyloid peptides (Aβ). In this paper, we showed that Aβ(1-42) and isoAβ(1-42) in human neuroblastoma cells SK-N-SH and promonocyte THP-1 activated the production of tumor necrosis factor (TNFα). Notably, isoAβ(1-42) had the strongest effect on the increase in the level of TNFα. The addition of recombinant heat-shock protein HSP70 reduces TNFα production induced by Aβ, which leads to a decrease in neuronal cell damage at the organism level.

Original language	English
Pages (from-to)	930-932
Number of pages	3
Journal	Molecular Biology
Volume	50
Issue number	6
DOIs	https://doi.org/10.1134/S0026893316060236
State	Published - 1 Nov 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016, Pleiades Publishing, Inc.

Keywords

HSP70
TNFα
neuroblastoma cells SK-N-SH
promonocyte cells THP-1
β-amyloid peptide
Аβ(1-42)

ASJC Scopus subject areas

Biophysics
Structural Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1134/S0026893316060236

Cite this

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title = "Heat-shock protein HSP70 reduces the secretion of TNFα by neuroblastoma cells and human monocytes induced with beta-amyloid peptides",

abstract = "The progress of neurodegeneration in Alzheimer{\textquoteright}s disease is closely associated with inflammatory processes in the brain tissues induced by beta-amyloid peptides (Aβ). In this paper, we showed that Aβ(1-42) and isoAβ(1-42) in human neuroblastoma cells SK-N-SH and promonocyte THP-1 activated the production of tumor necrosis factor (TNFα). Notably, isoAβ(1-42) had the strongest effect on the increase in the level of TNFα. The addition of recombinant heat-shock protein HSP70 reduces TNFα production induced by Aβ, which leads to a decrease in neuronal cell damage at the organism level.",

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AU - Yurinskaya, M. M.

AU - Mit’kevich, V. A.

AU - Evgen’ev, M. B.

AU - Makarov, A. A.

AU - Vinokurov, M. G.

PY - 2016/11/1

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AB - The progress of neurodegeneration in Alzheimer’s disease is closely associated with inflammatory processes in the brain tissues induced by beta-amyloid peptides (Aβ). In this paper, we showed that Aβ(1-42) and isoAβ(1-42) in human neuroblastoma cells SK-N-SH and promonocyte THP-1 activated the production of tumor necrosis factor (TNFα). Notably, isoAβ(1-42) had the strongest effect on the increase in the level of TNFα. The addition of recombinant heat-shock protein HSP70 reduces TNFα production induced by Aβ, which leads to a decrease in neuronal cell damage at the organism level.

KW - HSP70

KW - TNFα

KW - neuroblastoma cells SK-N-SH

KW - promonocyte cells THP-1

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Heat-shock protein HSP70 reduces the secretion of TNFα by neuroblastoma cells and human monocytes induced with beta-amyloid peptides

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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