TY - JOUR
T1 - Haptoglobin phenotype in age-related macular degeneration patients
AU - Seider, Nir
AU - Beiran, Itzchak
AU - Miller-Lotan, Rachel
AU - Dori, Dalia
AU - Karp, Jacob
AU - Miller, Benjamin
AU - Levy, Andrew P.
PY - 2003/11
Y1 - 2003/11
N2 - PURPOSE: To investigate a possible role of the haptoglobin phenotype in the development of exudative age-related macular degeneration (AMD) in human subjects. DESIGN: Prospective, observational, comparative population study. METHODS: The study was carried out in an institutional setting. All patients referred because of exudative AMD in one eye during an 18-month period were included in the study group. A group of patients treated for other ocular diseases and not having AMD in either eye served as control. Haptoglobin phenotype was determined from a blood sample drawn from each patient in both the study and control groups. The main outcome measure was the distribution of the haptoglobin phenotype in the study and control group. RESULTS: One hundred eighty-five participants were included in the study. Ninety-eight had exudative AMD, and 87 were AMD-free. The difference between the study and control groups in distribution of the haptoglobin phenotype was found to be statistically insignificant. CONCLUSIONS: Our results suggest that the haptoglobin phenotype has no effect on the prevalence of exudative AMD.
AB - PURPOSE: To investigate a possible role of the haptoglobin phenotype in the development of exudative age-related macular degeneration (AMD) in human subjects. DESIGN: Prospective, observational, comparative population study. METHODS: The study was carried out in an institutional setting. All patients referred because of exudative AMD in one eye during an 18-month period were included in the study group. A group of patients treated for other ocular diseases and not having AMD in either eye served as control. Haptoglobin phenotype was determined from a blood sample drawn from each patient in both the study and control groups. The main outcome measure was the distribution of the haptoglobin phenotype in the study and control group. RESULTS: One hundred eighty-five participants were included in the study. Ninety-eight had exudative AMD, and 87 were AMD-free. The difference between the study and control groups in distribution of the haptoglobin phenotype was found to be statistically insignificant. CONCLUSIONS: Our results suggest that the haptoglobin phenotype has no effect on the prevalence of exudative AMD.
UR - http://www.scopus.com/inward/record.url?scp=0142195784&partnerID=8YFLogxK
U2 - 10.1016/S0002-9394(03)00575-0
DO - 10.1016/S0002-9394(03)00575-0
M3 - Article
C2 - 14597045
AN - SCOPUS:0142195784
SN - 0002-9394
VL - 136
SP - 911
EP - 914
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 5
ER -
