Greater hippocampal volume is associated with PTSD treatment response

Mikael Rubin; Erel Shvil; Santiago Papini; Binod T. Chhetry; Liat Helpman; John C. Markowitz; J. John Mann; Yuval Neria

doi:10.1016/j.pscychresns.2016.05.001

Greater hippocampal volume is associated with PTSD treatment response

Mikael Rubin, Erel Shvil, Santiago Papini, Binod T. Chhetry, Liat Helpman, John C. Markowitz, J. John Mann, Yuval Neria

Research output: Contribution to journal › Article › peer-review

Abstract

Previous research associates smaller hippocampal volume with posttraumatic stress disorder (PTSD). It is unclear, however, whether treatment affects hippocampal volume or vice versa. Seventy-six subjects, 40 PTSD patients and 36 matched trauma-exposed healthy resilient controls, underwent clinical assessments and magnetic resonance imaging (MRI) at baseline, and 10 weeks later, during which PTSD patients completed ten weeks of Prolonged Exposure (PE) treatment. The resilient controls and treatment responders (n=23) had greater baseline hippocampal volume than treatment non-responders (n=17) (p=0.012 and p=0.050, respectively), perhaps due to more robust fear-extinction capacity in both the initial phase after exposure to trauma and during treatment.

Original language	English
Pages (from-to)	36-39
Number of pages	4
Journal	Psychiatry Research - Neuroimaging
Volume	252
DOIs	https://doi.org/10.1016/j.pscychresns.2016.05.001
State	Published - 30 Jun 2016
Externally published	Yes

Bibliographical note

Funding Information:
Preparation of this study was supported by R01 Grants MH072833 and MH105355 from the National Institute of Mental Health (Dr. Neria, principal investigator), and the New York State Psychiatric Institute. Dr. Helpman is supported by National Institutes of Health (NIH) grant 5T32MH096724-03.

Publisher Copyright:
© 2016 Elsevier Ireland Ltd.

Keywords

Hippocampus
MRI
PTSD
Prolonged Exposure Treatment
Resilience
Treatment Response

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

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10.1016/j.pscychresns.2016.05.001

Cite this

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title = "Greater hippocampal volume is associated with PTSD treatment response",

abstract = "Previous research associates smaller hippocampal volume with posttraumatic stress disorder (PTSD). It is unclear, however, whether treatment affects hippocampal volume or vice versa. Seventy-six subjects, 40 PTSD patients and 36 matched trauma-exposed healthy resilient controls, underwent clinical assessments and magnetic resonance imaging (MRI) at baseline, and 10 weeks later, during which PTSD patients completed ten weeks of Prolonged Exposure (PE) treatment. The resilient controls and treatment responders (n=23) had greater baseline hippocampal volume than treatment non-responders (n=17) (p=0.012 and p=0.050, respectively), perhaps due to more robust fear-extinction capacity in both the initial phase after exposure to trauma and during treatment.",

keywords = "Hippocampus, MRI, PTSD, Prolonged Exposure Treatment, Resilience, Treatment Response",

author = "Mikael Rubin and Erel Shvil and Santiago Papini and Chhetry, {Binod T.} and Liat Helpman and Markowitz, {John C.} and Mann, {J. John} and Yuval Neria",

note = "Funding Information: Preparation of this study was supported by R01 Grants MH072833 and MH105355 from the National Institute of Mental Health (Dr. Neria, principal investigator), and the New York State Psychiatric Institute. Dr. Helpman is supported by National Institutes of Health (NIH) grant 5T32MH096724-03. Publisher Copyright: {\textcopyright} 2016 Elsevier Ireland Ltd.",

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AU - Rubin, Mikael

AU - Shvil, Erel

AU - Papini, Santiago

AU - Chhetry, Binod T.

AU - Helpman, Liat

AU - Markowitz, John C.

AU - Mann, J. John

AU - Neria, Yuval

N1 - Funding Information: Preparation of this study was supported by R01 Grants MH072833 and MH105355 from the National Institute of Mental Health (Dr. Neria, principal investigator), and the New York State Psychiatric Institute. Dr. Helpman is supported by National Institutes of Health (NIH) grant 5T32MH096724-03. Publisher Copyright: © 2016 Elsevier Ireland Ltd.

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AB - Previous research associates smaller hippocampal volume with posttraumatic stress disorder (PTSD). It is unclear, however, whether treatment affects hippocampal volume or vice versa. Seventy-six subjects, 40 PTSD patients and 36 matched trauma-exposed healthy resilient controls, underwent clinical assessments and magnetic resonance imaging (MRI) at baseline, and 10 weeks later, during which PTSD patients completed ten weeks of Prolonged Exposure (PE) treatment. The resilient controls and treatment responders (n=23) had greater baseline hippocampal volume than treatment non-responders (n=17) (p=0.012 and p=0.050, respectively), perhaps due to more robust fear-extinction capacity in both the initial phase after exposure to trauma and during treatment.

KW - Hippocampus

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KW - PTSD

KW - Prolonged Exposure Treatment

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Greater hippocampal volume is associated with PTSD treatment response

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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