Gray matter volumes and cognitive ability in the epileptogenic brain malformation of periventricular nodular heterotopia

Linsey M. Walker; Tami Katzir; Tianming Liu; Jenny Ly; Kathleen Corriveau; Mirit Barzillai; Felicia Chu; Margaret G. O'Connor; David B. Hackney; Bernard S. Chang

doi:10.1016/j.yebeh.2009.05.009

Gray matter volumes and cognitive ability in the epileptogenic brain malformation of periventricular nodular heterotopia

Linsey M. Walker, Tami Katzir, Tianming Liu, Jenny Ly, Kathleen Corriveau, Mirit Barzillai, Felicia Chu, Margaret G. O'Connor, David B. Hackney, Bernard S. Chang

Research output: Contribution to journal › Article › peer-review

Abstract

Periventricular nodular heterotopia (PNH) is a brain malformation clinically characterized by the triad of epilepsy, normal intelligence, and dyslexia. We investigated the structure-function relationship between cerebral volumes and cognitive ability in this disorder by studying 12 subjects with PNH and 6 controls using volumetric analysis of high-resolution anatomical MRI and neuropsychological testing. Total cerebral volumes and specific brain compartment volumes (gray matter, white matter, and cerebrospinal fluid) in subjects with PNH were comparable to those in controls. There was a negative correlation between heterotopic gray matter volume and cortical gray matter volume. Cerebral and cortical volumes in PNH did not correlate with Full Scale IQ, unlike in normal individuals. Our findings support the idea that heterotopic nodules contain misplaced neurons that would normally have migrated to the cortex, and suggest that structural correlates of normal cognitive ability may be different in the setting of neuronal migration failure.

Original language	English
Pages (from-to)	456-460
Number of pages	5
Journal	Epilepsy and Behavior
Volume	15
Issue number	4
DOIs	https://doi.org/10.1016/j.yebeh.2009.05.009
State	Published - Aug 2009

Bibliographical note

Funding Information:
We thank all of our subjects for participating in this study; without them this research would not have been possible. B.S.C. was supported by the National Institute of Neurological Disorders and Stroke (Grant K23 NS049159). B.S.C. and T.K. were supported by the Mind–Brain–Behavior Initiative of Harvard University.

Keywords

Intelligence
Malformation of cortical development
Periventricular nodular heterotopia
Volumetric magnetic resonance imaging

ASJC Scopus subject areas

Neurology
Clinical Neurology
Behavioral Neuroscience

Access to Document

10.1016/j.yebeh.2009.05.009

Cite this

@article{71e2d74a6a874408bbaade413cf83156,

title = "Gray matter volumes and cognitive ability in the epileptogenic brain malformation of periventricular nodular heterotopia",

abstract = "Periventricular nodular heterotopia (PNH) is a brain malformation clinically characterized by the triad of epilepsy, normal intelligence, and dyslexia. We investigated the structure-function relationship between cerebral volumes and cognitive ability in this disorder by studying 12 subjects with PNH and 6 controls using volumetric analysis of high-resolution anatomical MRI and neuropsychological testing. Total cerebral volumes and specific brain compartment volumes (gray matter, white matter, and cerebrospinal fluid) in subjects with PNH were comparable to those in controls. There was a negative correlation between heterotopic gray matter volume and cortical gray matter volume. Cerebral and cortical volumes in PNH did not correlate with Full Scale IQ, unlike in normal individuals. Our findings support the idea that heterotopic nodules contain misplaced neurons that would normally have migrated to the cortex, and suggest that structural correlates of normal cognitive ability may be different in the setting of neuronal migration failure.",

keywords = "Intelligence, Malformation of cortical development, Periventricular nodular heterotopia, Volumetric magnetic resonance imaging",

author = "Walker, {Linsey M.} and Tami Katzir and Tianming Liu and Jenny Ly and Kathleen Corriveau and Mirit Barzillai and Felicia Chu and O'Connor, {Margaret G.} and Hackney, {David B.} and Chang, {Bernard S.}",

note = "Funding Information: We thank all of our subjects for participating in this study; without them this research would not have been possible. B.S.C. was supported by the National Institute of Neurological Disorders and Stroke (Grant K23 NS049159). B.S.C. and T.K. were supported by the Mind–Brain–Behavior Initiative of Harvard University.",

year = "2009",

month = aug,

doi = "10.1016/j.yebeh.2009.05.009",

language = "English",

volume = "15",

pages = "456--460",

journal = "Epilepsy and Behavior",

issn = "1525-5050",

publisher = "Academic Press Inc.",

number = "4",

}

TY - JOUR

T1 - Gray matter volumes and cognitive ability in the epileptogenic brain malformation of periventricular nodular heterotopia

AU - Walker, Linsey M.

AU - Katzir, Tami

AU - Liu, Tianming

AU - Ly, Jenny

AU - Corriveau, Kathleen

AU - Barzillai, Mirit

AU - Chu, Felicia

AU - O'Connor, Margaret G.

AU - Hackney, David B.

AU - Chang, Bernard S.

N1 - Funding Information: We thank all of our subjects for participating in this study; without them this research would not have been possible. B.S.C. was supported by the National Institute of Neurological Disorders and Stroke (Grant K23 NS049159). B.S.C. and T.K. were supported by the Mind–Brain–Behavior Initiative of Harvard University.

PY - 2009/8

Y1 - 2009/8

N2 - Periventricular nodular heterotopia (PNH) is a brain malformation clinically characterized by the triad of epilepsy, normal intelligence, and dyslexia. We investigated the structure-function relationship between cerebral volumes and cognitive ability in this disorder by studying 12 subjects with PNH and 6 controls using volumetric analysis of high-resolution anatomical MRI and neuropsychological testing. Total cerebral volumes and specific brain compartment volumes (gray matter, white matter, and cerebrospinal fluid) in subjects with PNH were comparable to those in controls. There was a negative correlation between heterotopic gray matter volume and cortical gray matter volume. Cerebral and cortical volumes in PNH did not correlate with Full Scale IQ, unlike in normal individuals. Our findings support the idea that heterotopic nodules contain misplaced neurons that would normally have migrated to the cortex, and suggest that structural correlates of normal cognitive ability may be different in the setting of neuronal migration failure.

AB - Periventricular nodular heterotopia (PNH) is a brain malformation clinically characterized by the triad of epilepsy, normal intelligence, and dyslexia. We investigated the structure-function relationship between cerebral volumes and cognitive ability in this disorder by studying 12 subjects with PNH and 6 controls using volumetric analysis of high-resolution anatomical MRI and neuropsychological testing. Total cerebral volumes and specific brain compartment volumes (gray matter, white matter, and cerebrospinal fluid) in subjects with PNH were comparable to those in controls. There was a negative correlation between heterotopic gray matter volume and cortical gray matter volume. Cerebral and cortical volumes in PNH did not correlate with Full Scale IQ, unlike in normal individuals. Our findings support the idea that heterotopic nodules contain misplaced neurons that would normally have migrated to the cortex, and suggest that structural correlates of normal cognitive ability may be different in the setting of neuronal migration failure.

KW - Intelligence

KW - Malformation of cortical development

KW - Periventricular nodular heterotopia

KW - Volumetric magnetic resonance imaging

UR - http://www.scopus.com/inward/record.url?scp=67849132401&partnerID=8YFLogxK

U2 - 10.1016/j.yebeh.2009.05.009

DO - 10.1016/j.yebeh.2009.05.009

M3 - Article

C2 - 19541546

AN - SCOPUS:67849132401

SN - 1525-5050

VL - 15

SP - 456

EP - 460

JO - Epilepsy and Behavior

JF - Epilepsy and Behavior

IS - 4

ER -

Gray matter volumes and cognitive ability in the epileptogenic brain malformation of periventricular nodular heterotopia

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this