Germline amino acid diversity in B cell receptors is a good predictor of somatic selection pressures

Immunology and Microbiology

• B-Cell Receptor 100%
• Somatic Mutation 100%
• Infectious Agent 50%
• B Cell 50%
• Immune Response 50%
• High Throughput Sequencing 50%
• Vaccination Policy 50%
• Influenza 50%
• Gene Sequence 50%
• Cell Clone 50%
• Heavy Chain 50%
• Immune Repertoire 50%
• Adaptive Immune System 50%
• Complementarity Determining Region 50%
• Framework Region 50%
• Immunoglobulin Heavy Chain 50%

Keyphrases

• Selection Pressure 100%
• B Cell Receptor 100%
• Germ Cells 100%
• Amino Acid Diversity 100%
• Somatic Selection 100%
• Amino Acids 30%
• Somatic mutation 20%
• Heavy Chain 20%
• V Genes 20%
• Somatic Diversity 20%
• Strong Correlation 10%
• Gene Sequencing 10%
• Recombination 10%
• Immune Response 10%
• Influenza 10%
• Revaccination 10%
• Adaptive Immune Response 10%
• B-cell Clone 10%
• Systemability 10%
• Immune Repertoire 10%
• Gene Segment 10%
• Specific Positions 10%
• Specific Receptor 10%
• Complementarity-determining Region 3 (CDR3) 10%
• Germline Gene 10%
• Framework Regions 10%
• Amino Acid Usage 10%
• Germline Repertoire 10%
• 454 High-throughput Sequencing 10%
• Hypermutation 10%
• Amino Acid Position 10%
• Priori Model 10%

Biochemistry, Genetics and Molecular Biology

• Amino Acids 100%
• Germ Cell 100%
• B-Cell Receptor 100%
• Germline 100%
• Somatic Mutation 16%
• Heavy Chain 16%
• Gene Sequence 8%
• Infectious Agent 8%
• B Cell 8%
• Intravenous Immunoglobulin 8%
• Immune Response 8%
• High Throughput Sequencing 8%
• Cell Clone 8%
• Adaptive Immunity 8%
• Gene Segment 8%
• Complementarity Determining Region 8%
• Framework Region 8%