Genotyping of geographically diverse Druze trios reveals substructure and a recent bottleneck

Jamal Zidan, Dan Ben-Avraham, Shai Carmi, Taiseer Maray, Eitan Friedman, Gil Atzmon

Research output: Contribution to journalArticlepeer-review

Abstract

Druze individuals rarely marry outside their faith (often practicing consanguinity) and are thus believed to form a genetic isolate. To comprehensively characterize the genetic structure of the Druze population, we recruited and genotyped 40 parent-offspring trios from the Upper Galilee in Israel and the Golan Heights, attempting to capture different extended families (clans) across various geographical locations. Principal component (PC) and ADMIXTURE analyses demonstrated that Druze are close to, yet distinct from, other Middle-Eastern groups (Bedouins and Palestinians), supporting the Druze's Middle-Eastern origin and their recent genetic isolation. Reconstruction of the Druze demographic history using identical-by-descent (IBD) segments suggested an ≈15-fold reduction in population size taking place ≈22-47 generations ago, close to the documented time of the foundation of the Druze faith at the 11th century. Combining the Galilee and Golan Druze genotypes with previously published data on Druze from the Carmel (Israel) and Lebanon demonstrated that all four Druze communities are genetically distinct. The Lebanese group shared less IBD segments (within the group and with other groups) compared with the Israeli Druze and showed higher heterozygosity (suggesting less consanguinity), but was less diverse in PC space. These findings suggest complex recent and ancient demographic history of the Druze population.

Original languageEnglish
Pages (from-to)1093-1099
Number of pages7
JournalEuropean Journal of Human Genetics
Volume23
Issue number8
DOIs
StatePublished - 21 Aug 2015
Externally publishedYes

Bibliographical note

Funding Information:
This study was in part sponsored by a grant from the Binational Science Foundation (BSF) to EF and Harry Ostrer and generous donations from private donors to the Golan for Development organization and the Oncology Institute at the Ziv medical center. SC acknowledges financial support from the Human Frontier Science Program and GA NIH (1R01AG042188).

Publisher Copyright:
© 2015 Macmillan Publishers Limited All rights reserved.

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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