The genetic analysis of behavior has a long history, yet it is only 25 years since the first 'behavioral' genes were identified at the molecular level. These advances were based on prior genomic screens involving random chemical mutagenesis, initially in the fruitfly Drosophila melanogaster and then later in the mouse. Several 'forward genetic' techniques now exist to complement this basic approach, but 'reverse genetics,' whereby DNA or mRNA can be identified, targeted, and manipulated, can also be utilized to create mutant phenotypes. We provide some examples of the successes of these approaches involving circadian rhythms, sexual behavior, and aggression.
|Title of host publication||Encyclopedia of Animal Behavior|
|Number of pages||9|
|State||Published - 1 Jan 2009|
Bibliographical notePublisher Copyright:
© 2010 Elsevier Ltd All rights reserved.
ASJC Scopus subject areas
- Agricultural and Biological Sciences (all)