Functionally significant insulin-like growth factor I receptor mutations in centenarians

Keyphrases

• Centenarians 100%
• Insulin-like Growth Factor 1 Receptor (IGF1R) 100%
• Growth Factors 80%
• Insulin-like 80%
• Receptor Gene 40%
• Insulin 40%
• Human Lifespan 40%
• Ashkenazi Jews 20%
• Gender-specific 20%
• Underrepresentation 20%
• Sequence Analysis 20%
• Reducing Activity 20%
• Genetic Modification 20%
• Human Longevity 20%
• Lymphocytes 20%
• Human Population 20%
• Laboratory Animals 20%
• Gain-of-function mutation 20%
• Genetic Variation 20%
• Biochemical Variation 20%
• Small Stature 20%
• Partial Loss 20%
• Female Offspring 20%
• Phenotypic Variation 20%
• Wear-and-Tear 20%
• Fitness Cost 20%
• IGF Signaling Pathway 20%
• Altered Signaling 20%
• Insulin-like Growth factor-1 20%
• Compound Heterozygous mutation 20%
• Gene mutation 20%
• Life Extension 20%
• Gene Encoding 20%
• World Register of Marine Species 20%
• Evolutionary Trade-offs 20%

Biochemistry, Genetics and Molecular Biology

• Insulin-Like Growth Factor 1 100%
• Insulin-Like Growth Factor 1 Receptor 100%
• Lifespan 50%
• Offspring 37%
• Receptor Gene 25%
• Insulin Blood Level 25%
• Insulin 25%
• Signal Transduction 12%
• Genetics 12%
• Gene Mutation 12%
• Protein Sequencing 12%
• Loss of Function Mutation 12%
• Body Height 12%
• Experimental Animal 12%
• Phenotypic Variation 12%
• Lymphocyte 12%