Four Genome-Wide Association Studies Identify New Extreme Longevity Variants

Paola Sebastiani; Anastasia Gurinovich; Harold Bae; Stacy Andersen; Alberto Malovini; Gil Atzmon; Francesco Villa; Aldi T. Kraja; Danny Ben-Avraham; Nir Barzilai; Annibale Puca; Thomas T. Perls

doi:10.1093/gerona/glx027

Four Genome-Wide Association Studies Identify New Extreme Longevity Variants

Paola Sebastiani, Anastasia Gurinovich, Harold Bae, Stacy Andersen, Alberto Malovini, Gil Atzmon, Francesco Villa, Aldi T. Kraja, Danny Ben-Avraham, Nir Barzilai, Annibale Puca, Thomas T. Perls

Department of Human Biology

Research output: Contribution to journal › Article › peer-review

Abstract

The search for the genetic determinants of extreme human longevity has been challenged by the phenotype's rarity and its nonspecific definition by investigators. To address these issues, we established a consortium of four studies of extreme longevity that contributed 2,070 individuals who survived to the oldest one percentile of survival for the 1900 U.S. birth year cohort. We conducted various analyses to discover longevity-associated variants (LAV) and characterized those LAVs that differentiate survival to extreme age at death (eSAVs) from those LAVs that become more frequent in centenarians because of mortality selection (eg, survival to younger years). The analyses identified new rare variants in chromosomes 4 and 7 associated with extreme survival and with reduced risk for cardiovascular disease and Alzheimer's disease. The results confirm the importance of studying truly rare survival to discover those combinations of common and rare variants associated with extreme longevity and longer health span.

Original language	English
Pages (from-to)	1453-1464
Number of pages	12
Journal	Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume	72
Issue number	11
DOIs	https://doi.org/10.1093/gerona/glx027
State	Published - 1 Nov 2017

Bibliographical note

Publisher Copyright:
© The Author 2017.

Keywords

Genetic profiles
Genetic variants
Healthy aging
Human longevity

ASJC Scopus subject areas

Aging
Geriatrics and Gerontology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/gerona/glx027

Cite this

Sebastiani, P., Gurinovich, A., Bae, H., Andersen, S., Malovini, A., Atzmon, G., Villa, F., Kraja, A. T., Ben-Avraham, D., Barzilai, N., Puca, A., & Perls, T. T. (2017). Four Genome-Wide Association Studies Identify New Extreme Longevity Variants. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 72(11), 1453-1464. https://doi.org/10.1093/gerona/glx027

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Sebastiani, P, Gurinovich, A, Bae, H, Andersen, S, Malovini, A, Atzmon, G, Villa, F, Kraja, AT, Ben-Avraham, D, Barzilai, N, Puca, A & Perls, TT 2017, 'Four Genome-Wide Association Studies Identify New Extreme Longevity Variants', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 72, no. 11, pp. 1453-1464. https://doi.org/10.1093/gerona/glx027

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AU - Sebastiani, Paola

AU - Gurinovich, Anastasia

AU - Bae, Harold

AU - Andersen, Stacy

AU - Malovini, Alberto

AU - Atzmon, Gil

AU - Villa, Francesco

AU - Kraja, Aldi T.

AU - Ben-Avraham, Danny

AU - Barzilai, Nir

AU - Puca, Annibale

AU - Perls, Thomas T.

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Four Genome-Wide Association Studies Identify New Extreme Longevity Variants

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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