Formation of alternative proteasomes: Same lady, different cap?

Elah Pick; Tali S. Berman

doi:10.1016/j.febslet.2013.01.014

Formation of alternative proteasomes: Same lady, different cap?

Elah Pick, Tali S. Berman

Faculty of Natural Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The 26S proteasome is thought to be a homogenous complex, consisting of a 20S proteolytic core and a 19S regulatory particle that is required for its activation. Two groups have recently reported the activation of archeal 20S by a p97-related double-ring AAA+ ATPase complex, in a similar fashion to that reported for 19S. Since p97 is found in eukaryotes, the existence of a parallel setting in higher organisms is intriguing. Herein, we present supporting data and hypothesize that in eukaryotes, p97 and CSN form a promiscuous, hence hard-to-detect, "alternative cap", enabling the prompt and precise elimination of particular substrates.

Original language	English
Pages (from-to)	389-393
Number of pages	5
Journal	FEBS Letters
Volume	587
Issue number	5
DOIs	https://doi.org/10.1016/j.febslet.2013.01.014
State	Published - 1 Mar 2013

Bibliographical note

Funding Information:
We would like to thank the Israeli Science Foundation (grant no. EP355/10 for EP), for financial support of our studies.

Keywords

26S proteasome
COP9 signalosome (CSN)
Cullin RING E3 ligases
P97
Ubiquitin
VAT

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/j.febslet.2013.01.014

Cite this

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title = "Formation of alternative proteasomes: Same lady, different cap?",

abstract = "The 26S proteasome is thought to be a homogenous complex, consisting of a 20S proteolytic core and a 19S regulatory particle that is required for its activation. Two groups have recently reported the activation of archeal 20S by a p97-related double-ring AAA+ ATPase complex, in a similar fashion to that reported for 19S. Since p97 is found in eukaryotes, the existence of a parallel setting in higher organisms is intriguing. Herein, we present supporting data and hypothesize that in eukaryotes, p97 and CSN form a promiscuous, hence hard-to-detect, {"}alternative cap{"}, enabling the prompt and precise elimination of particular substrates.",

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note = "Funding Information: We would like to thank the Israeli Science Foundation (grant no. EP355/10 for EP), for financial support of our studies.",

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doi = "10.1016/j.febslet.2013.01.014",

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T2 - Same lady, different cap?

AU - Pick, Elah

AU - Berman, Tali S.

N1 - Funding Information: We would like to thank the Israeli Science Foundation (grant no. EP355/10 for EP), for financial support of our studies.

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KW - COP9 signalosome (CSN)

KW - Cullin RING E3 ligases

KW - P97

KW - Ubiquitin

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JO - FEBS Letters

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Formation of alternative proteasomes: Same lady, different cap?

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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