Fear conditioning drives profilin into amygdala dendritic spines

Raphael Lamprecht; Claudia R. Farb; Sarina M. Rodrigues; Joseph E. LeDoux

doi:10.1038/nn1672

Fear conditioning drives profilin into amygdala dendritic spines

Raphael Lamprecht, Claudia R. Farb, Sarina M. Rodrigues, Joseph E. LeDoux

Department of Neurobiology

Research output: Contribution to journal › Article › peer-review

Abstract

Changes in spine morphology may underlie memory formation, but the molecular mechanisms that subserve such alterations are poorly understood. Here we show that fear conditioning in rats leads to the movement of profilin, an actin polymerization-regulatory protein, into dendritic spines in the lateral amygdala and that these spines undergo enlargements in their postsynaptic densities (PSDs). A greater proportion of profilin-containing spines with enlarged PSDs could contribute to the enhancement of associatively induced synaptic responses in the lateral amygdala following fear learning.

Original language	English
Pages (from-to)	481-483
Number of pages	3
Journal	Nature Neuroscience
Volume	9
Issue number	4
DOIs	https://doi.org/10.1038/nn1672
State	Published - Apr 2006

Bibliographical note

Funding Information:
We thank D. Bush for his helpful discussions about this work. This research was supported in part by National Institutes of Health grants MH58911, MH46516, MH38774 and MH067048.

ASJC Scopus subject areas

General Neuroscience

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10.1038/nn1672

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title = "Fear conditioning drives profilin into amygdala dendritic spines",

abstract = "Changes in spine morphology may underlie memory formation, but the molecular mechanisms that subserve such alterations are poorly understood. Here we show that fear conditioning in rats leads to the movement of profilin, an actin polymerization-regulatory protein, into dendritic spines in the lateral amygdala and that these spines undergo enlargements in their postsynaptic densities (PSDs). A greater proportion of profilin-containing spines with enlarged PSDs could contribute to the enhancement of associatively induced synaptic responses in the lateral amygdala following fear learning.",

author = "Raphael Lamprecht and Farb, {Claudia R.} and Rodrigues, {Sarina M.} and LeDoux, {Joseph E.}",

note = "Funding Information: We thank D. Bush for his helpful discussions about this work. This research was supported in part by National Institutes of Health grants MH58911, MH46516, MH38774 and MH067048.",

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AU - Rodrigues, Sarina M.

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N2 - Changes in spine morphology may underlie memory formation, but the molecular mechanisms that subserve such alterations are poorly understood. Here we show that fear conditioning in rats leads to the movement of profilin, an actin polymerization-regulatory protein, into dendritic spines in the lateral amygdala and that these spines undergo enlargements in their postsynaptic densities (PSDs). A greater proportion of profilin-containing spines with enlarged PSDs could contribute to the enhancement of associatively induced synaptic responses in the lateral amygdala following fear learning.

AB - Changes in spine morphology may underlie memory formation, but the molecular mechanisms that subserve such alterations are poorly understood. Here we show that fear conditioning in rats leads to the movement of profilin, an actin polymerization-regulatory protein, into dendritic spines in the lateral amygdala and that these spines undergo enlargements in their postsynaptic densities (PSDs). A greater proportion of profilin-containing spines with enlarged PSDs could contribute to the enhancement of associatively induced synaptic responses in the lateral amygdala following fear learning.

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Fear conditioning drives profilin into amygdala dendritic spines

Abstract

Bibliographical note

ASJC Scopus subject areas

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