Fatty acids rehabilitated long-term neurodegenerative: like symptoms in olfactory bulbectomized rats

Shlomo Yehuda, Sharon Rabinovitz

Research output: Contribution to journalArticlepeer-review


Our previous study demonstrated that an olfactory bulbectomy in rats induced short-term, multifaceted, devastating Alzheimer’s-like effects, which included cognitive impairment, hyperactivity, hyperthermia, and increased levels of homocysteine and pro-inflammatory cytokines, including IL-17A. In addition, the rats exhibited an increase in the hyperphosphorylation of brain Tau proteins and in the number of neurofibrillary tangles. Here, we examined the long-term effects of the surgery and found that olfactory bulbectomy also rendered the rats to become anemic with brain iron overload. Additionally, a significant reduction in the membrane fluidity index in frontal cortex synaptosomes was found. Treatment with a mixture of n − 3/n − 6 of fatty acids restored the unwanted effect. The beneficial effects of fatty acids are mediated via the effects of fatty acids on the neuronal membrane structure and fluidity. These findings are similar to Alzheimer’s symptoms, which suggest this model can be used as an animal model for Alzheimer’s disease. We recommend using this model to scan potential new anti-Alzheimer’s drugs.

Original languageEnglish
Pages (from-to)629-641
Number of pages13
JournalJournal of Neural Transmission
Issue number5
StatePublished - 1 May 2015

Bibliographical note

Publisher Copyright:
© 2014, Springer-Verlag Wien.


  • Alzheimer: fatty acids
  • Anemia
  • Animal model
  • Brain iron overload
  • Cholesterol
  • Cognition
  • IL-17
  • Membrane fluidity
  • Olfactory bulbectomy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry


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