Familial clustering of classic Kaposi sarcoma

Emma Guttman-Yassky, Adina Cohen, Zippi Kra-Oz, Rachel Friedman-Birnbaum, Elli Sprecher, Neli Zaltzman, Eitan Friedman, Michael Silbermann, Dina Rubin, Shai Linn, Dennis Whitby, Osnat Gideoni, Shimon Pollack, Reuven Bergman, Ronit Sarid

Research output: Contribution to journalArticlepeer-review

Abstract

It is widely accepted that there is a causal association between Kaposi sarcoma-associated herpesvirus (KSHV) and Kaposi sarcoma (KS). However, the majority of individuals infected with KSHV never develop KS. Here, we present a unique familial case of classic KS, in which the disease occurs in 4 siblings who have no recognized underlying immunodeficiency. We examine risk factors that could play a role in this condition, including KSHV infection, KSHV DNA load, genetic variants of KSHV, infection with additional viruses, interleukin-6-promoter polymorphism, and HLA genotype. We hypothesize that a genetic susceptibility to KS, in combination with KSHV infection, may play an important role in the presented familial case.

Original languageEnglish
Pages (from-to)2023-2026
Number of pages4
JournalJournal of Infectious Diseases
Volume189
Issue number11
DOIs
StatePublished - 1 Apr 2004
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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