Factor mixture model of anxiety sensitivity and anxiety psychopathology vulnerability

Amit Bernstein, Timothy R. Stickle, Norman B. Schmidt

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The purpose of the present study was to shed light on the latent structure and nature of individual differences in anxiety sensitivity (AS) and related risk for psychopathology. Methods: The present study evaluated the latent structure of AS using factor mixture modeling (FMM; Lubke and Muthén, 2005) and tested the relations between the observed FMM-based model of AS and psychopathology in a large, diverse adult clinical research sample (N=481; 57.6% women; M(SD)age=36.6(15.0) years). Results: Findings showed that a two-class three-factor partially invariant model of AS demonstrated significantly better fit than a one-class dimensional model and more complex multi-class models. As predicted, risk conferred by AS taxonicity was specific to anxiety psychopathology, and not to other forms of psychopathology. Limitations: The sample was not epidemiologic, self-report and psychiatric interview data were used to index AS and psychopathology, and a cross-sectional design limited inference regarding the directionality of observed relations between AS and anxiety psychopathology. Conclusions: Findings are discussed with respect to the nature of AS and related anxiety psychopathology vulnerability specifically, as well as the implications of factor mixture modeling for advancing taxonomy of vulnerability and psychopathology more broadly.

Original languageEnglish
Pages (from-to)406-417
Number of pages12
JournalJournal of Affective Disorders
Volume149
Issue number1-3
DOIs
StatePublished - Jul 2013

Bibliographical note

Funding Information:
Dr. Bernstein recognizes the funding support from the Israeli Council for Higher Education Yigal Alon Fellowship, the European Union FP-7 Marie Curie Fellowship International Reintegration Grant, Psychology Beyond Borders Mission Award, Israel Science Foundation, the University of Haifa Research Authority Exploratory Grant, and the Rothschild-Caesarea Foundation’s Returning Scientists Project at the University of Haifa.

Keywords

  • Anxiety disorders
  • Anxiety sensitivity
  • Factor mixture modeling
  • Latent structure
  • Risk factor

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

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