Exploratory analysis of potential risk factors of a rare disease: Spatial distribution of adrenocortical carcinoma in Israel as a case study

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Abstract

The underlying assumption of the proposed exploratory approach is that, if the geographic patterns of different diseases are compared, the cases of a 'subject' disease should occur closer to cases of a disease with similar environmental risk factors (etiology) and farther away from cases of a disease with different etiology. In the present study, the performance of proposed approach is investigated by cross-examination of the spatial patterns of three widespread cancers - lung, larynx and colorectal (CRC) - with that of a rare malignant disease - Adrenocortical Carcinoma (ACC). As the analysis indicates, the spatial distribution of ACC is more likely to be related to hereditary factors than to environmental causes, in accordance with current knowledge about this rare disease.

Original languageEnglish
Pages (from-to)1738-1743
Number of pages6
JournalScience of the Total Environment
Volume407
Issue number5
DOIs
StatePublished - 15 Feb 2009

Keywords

  • Rare disease
  • Risk factors
  • Spatial clustering

ASJC Scopus subject areas

  • Pollution
  • Waste Management and Disposal
  • Environmental Engineering
  • Environmental Chemistry

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