Experience-induced transgenerational (re-)programming of neuronal structure and functions: Impact of stress prior and during pregnancy

Katharina Braun; Jörg Bock; Tamar Wainstock; Emmanuel Matas; Inna Gaisler-Salomon; Jörg Fegert; Ute Ziegenhain; Menahem Segal

doi:10.1016/j.neubiorev.2017.05.021

Experience-induced transgenerational (re-)programming of neuronal structure and functions: Impact of stress prior and during pregnancy

Katharina Braun, Jörg Bock, Tamar Wainstock, Emmanuel Matas, Inna Gaisler-Salomon, Jörg Fegert, Ute Ziegenhain, Menahem Segal

Department of Psychology

Research output: Contribution to journal › Review article › peer-review

Abstract

This review focuses on the inter- and transgenerational effects of stress experience prior to and during gestation. We provide an overview of findings from studies in humans as well as in animal models on brain structural and physiological functions and on the development of cognitive and executive functions. We also discuss the concept of stress-induced (re-)programming in more detail by highlighting epigenetic mechanisms and particularly those affecting the development of monoaminergic transmitter systems, which constitute the braińs reward system. As the majority of studies have focused on male individuals we will emphasize sex-specific differences in stress vulnerability and resilience. Finally, we offer some perspectives on the development of protective and therapeutic interventions in cognitive and emotional disturbances resulting from pre-conception and prenatal stress.

Original language	English
Pages (from-to)	281-296
Number of pages	16
Journal	Neuroscience and Biobehavioral Reviews
Volume	117
DOIs	https://doi.org/10.1016/j.neubiorev.2017.05.021
State	Published - Oct 2020

Bibliographical note

Funding Information:
Our work was supported by grants from the German Bundesministerium für Bildung und Forschung (BMBF) TransGen, 01KR1304B to KB, 01KR1304A to JF and UZ and UBICA, 01KR1207D to JB). We would like to thank Madeleine Stiefel for help with editorial work and Susann Becker for help with the artwork.

Publisher Copyright:
© 2017 Elsevier Ltd

Keywords

Dopamine
Epigenetics
Limbic
Neural development
Preconception stress
Prenatal stress
Psychopathology

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Cognitive Neuroscience
Behavioral Neuroscience

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10.1016/j.neubiorev.2017.05.021

Cite this

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title = "Experience-induced transgenerational (re-)programming of neuronal structure and functions: Impact of stress prior and during pregnancy",

abstract = "This review focuses on the inter- and transgenerational effects of stress experience prior to and during gestation. We provide an overview of findings from studies in humans as well as in animal models on brain structural and physiological functions and on the development of cognitive and executive functions. We also discuss the concept of stress-induced (re-)programming in more detail by highlighting epigenetic mechanisms and particularly those affecting the development of monoaminergic transmitter systems, which constitute the brai{\'n}s reward system. As the majority of studies have focused on male individuals we will emphasize sex-specific differences in stress vulnerability and resilience. Finally, we offer some perspectives on the development of protective and therapeutic interventions in cognitive and emotional disturbances resulting from pre-conception and prenatal stress.",

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author = "Katharina Braun and J{\"o}rg Bock and Tamar Wainstock and Emmanuel Matas and Inna Gaisler-Salomon and J{\"o}rg Fegert and Ute Ziegenhain and Menahem Segal",

note = "Funding Information: Our work was supported by grants from the German Bundesministerium f{\"u}r Bildung und Forschung (BMBF) TransGen, 01KR1304B to KB, 01KR1304A to JF and UZ and UBICA, 01KR1207D to JB). We would like to thank Madeleine Stiefel for help with editorial work and Susann Becker for help with the artwork. Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

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doi = "10.1016/j.neubiorev.2017.05.021",

language = "English",

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AU - Matas, Emmanuel

AU - Gaisler-Salomon, Inna

AU - Fegert, Jörg

AU - Ziegenhain, Ute

AU - Segal, Menahem

N1 - Funding Information: Our work was supported by grants from the German Bundesministerium für Bildung und Forschung (BMBF) TransGen, 01KR1304B to KB, 01KR1304A to JF and UZ and UBICA, 01KR1207D to JB). We would like to thank Madeleine Stiefel for help with editorial work and Susann Becker for help with the artwork. Publisher Copyright: © 2017 Elsevier Ltd

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KW - Epigenetics

KW - Limbic

KW - Neural development

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Experience-induced transgenerational (re-)programming of neuronal structure and functions: Impact of stress prior and during pregnancy

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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