Exogenous heat shock protein HSP70 reduces response of human neuroblastoma cells to lipopolysaccharide

M. M. Yurinskaya; S. Y. Funikov; M. B. Evgen’ev; M. G. Vinokurov

doi:10.1134/S1607672916040025

Exogenous heat shock protein HSP70 reduces response of human neuroblastoma cells to lipopolysaccharide

M. M. Yurinskaya, S. Y. Funikov, M. B. Evgen’ev, M. G. Vinokurov

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of exogenous heat shock protein HSP70 and lipopolysaccharide (LPS) on the production of reactive oxygen species (ROS), TNFα secretion, and mRNA expression by human neuroblastoma SK-N-SH cells. It was shown that exogenous HSP70 protects neuroblastoma cells from the action of LPS. The protection mechanism of HSP70 includes a reduction in the production of ROS and TNFα and a decrease in the expression of TLR4 and IL-1β mRNA in SK-N-SH cells induced by LPS.

Original language	English
Pages (from-to)	239-243
Number of pages	5
Journal	Doklady Biochemistry and Biophysics
Volume	469
Issue number	1
DOIs	https://doi.org/10.1134/S1607672916040025
State	Published - 1 Jul 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016, Pleiades Publishing, Ltd.

ASJC Scopus subject areas

Biophysics
Biochemistry
General Chemistry

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abstract = "The effect of exogenous heat shock protein HSP70 and lipopolysaccharide (LPS) on the production of reactive oxygen species (ROS), TNFα secretion, and mRNA expression by human neuroblastoma SK-N-SH cells. It was shown that exogenous HSP70 protects neuroblastoma cells from the action of LPS. The protection mechanism of HSP70 includes a reduction in the production of ROS and TNFα and a decrease in the expression of TLR4 and IL-1β mRNA in SK-N-SH cells induced by LPS.",

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AU - Evgen’ev, M. B.

AU - Vinokurov, M. G.

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AB - The effect of exogenous heat shock protein HSP70 and lipopolysaccharide (LPS) on the production of reactive oxygen species (ROS), TNFα secretion, and mRNA expression by human neuroblastoma SK-N-SH cells. It was shown that exogenous HSP70 protects neuroblastoma cells from the action of LPS. The protection mechanism of HSP70 includes a reduction in the production of ROS and TNFα and a decrease in the expression of TLR4 and IL-1β mRNA in SK-N-SH cells induced by LPS.

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Exogenous heat shock protein HSP70 reduces response of human neuroblastoma cells to lipopolysaccharide

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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