Exaggerated translation causes synaptic and behavioural aberrations associated with autism

Keyphrases

• Synaptic 100%
• Autism 100%
• Aberrations 100%
• Eukaryotic Translation Initiation Factor 4E (eIF4E) 80%
• Cap-dependent Translation 60%
• Autism Spectrum Disorder 40%
• Repetitive Behavior 40%
• Autistic Traits 40%
• Aberrant Behavior 40%
• Protein Synthesis 20%
• Hippocampus 20%
• Heterogeneous Groups 20%
• Pathophysiology 20%
• Medial Prefrontal Cortex (mPFC) 20%
• Genetic Variants 20%
• Single nucleotide Polymorphism 20%
• Striatum 20%
• Transgenic Mice 20%
• Early Onset 20%
• Synaptic Dysfunction 20%
• Neuropsychiatric Disorders 20%
• Causal Relationship 20%
• Social Interaction Deficits 20%
• Communication Ability 20%
• Social Interaction Skills 20%
• Translational Control 20%
• Perseverative Behavior 20%
• 4EGI-1 20%
• Common Molecular Mechanism 20%
• Translation Behavior 20%
• Translation Inhibitor 20%
• Promoter Activity 20%
• Impaired Communication 20%
• Intracerebroventricular Injection 20%

Biochemistry, Genetics and Molecular Biology

• Social Interaction 100%
• Eukaryotic Translation 100%
• Initiation Factor 100%
• EIF4E 100%
• Protein Biosynthesis 50%
• Genetic Divergence 50%
• Promoter Region 50%
• Single-Nucleotide Polymorphism 50%
• Transgenic Mouse 50%
• Chromosome 4q 50%

Neuroscience

• Autism 100%
• Behavior (Neuroscience) 60%
• Social Interaction 40%
• Behavior Disorder 40%
• Translation Initiation 40%
• Autism Spectrum Disorder 40%
• Hippocampus 20%
• Protein Biosynthesis 20%
• Prefrontal Cortex 20%
• Single-Nucleotide Polymorphism 20%
• Striatum 20%
• Compulsive Behavior 20%
• Promoter Region 20%
• Chromosome 4q 20%