Essential tremor prevalence is low in the druze population in northern israel

Judith Aharon-Peretz; Samih Badarny; Raphiq Ibrahim; Ruth Gershoni-Baruch; Gamal Hassoun

doi:10.5334/TOHM.90

Essential tremor prevalence is low in the druze population in northern israel

Judith Aharon-Peretz, Samih Badarny, Raphiq Ibrahim, Ruth Gershoni-Baruch, Gamal Hassoun

Department of Learning Disabilities

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Essential tremor (ET) and Parkinson’s disease (PD) are probably the most common movement disorders. As ethnic differences have been reported in ET, we designed the present study to evaluate the prevalence of ET and that of Parkinson’s disease (PD) in the Druze villages of northern Israel. Methods: A two-phase, door-to-door survey was undertaken. Residents aged ≥51 years who agreed to participate and answered ‘‘yes’’ to tremor or PD-related screening questions and 3% of subjects who screened negative were evaluated. Diagnostic criteria for ET were similar to those used in Sicilian and Spanish studies. PD was diagnosed according to Gelb’s criteria. Results: The target population consisted of 9,086, the study cohort of 3,980 residents. Tremor was observed in 36 subjects. In 27, the tremor fully met the criteria for ET. The prevalence of ET (age ≥65) was 1.49% (95% CI 0.91–2.07%). PD was diagnosed in 23 subjects. The prevalence of PD (age ≥65) was 1.13 (95% CI 0.62–1.64%). Leucine-rich repeat protein kinase 2 (G2019S mutation) was evaluated in subjects diagnosed with tremor PD and those screened for assessment of the validity of the questionnaire. None carried the mutation. Discussion: The prevalence of ET in the Druze population is low and similar to the prevalence of PD.

Original language	English
Journal	Tremor and Other Hyperkinetic Movements
Volume	2
DOIs	https://doi.org/10.5334/TOHM.90
State	Published - 2012

Bibliographical note

Funding Information:
* To whom correspondence should be addressed. E-mail: [email protected] Editor: Elan D. Louis, Columbia UniversityUnited States of America Received: November 29, 2011 Accepted: December 21, 2011 Published: March 22, 2012 Copyright: ’ 2012 Aharon-Peretz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution–Noncommercial–No Derivatives License, which permits the user to copy, distribute, and transmit the work provided that the original author(s) and source are credited; that no commercial use is made of the work; and that the work is not altered or transformed. Funding: This study was supported by a research grant from the Israeli Ministry of Science and Technology. Competing Interests: The authors report no conflict of interest.

Publisher Copyright:
© 2012 Aharon-Peretz et al.

Keywords

Druze
Epidemiology
Essential tremor
Leucine-rich repeat protein kinase 2
Parkinson’s disease

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.5334/TOHM.90

Cite this

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title = "Essential tremor prevalence is low in the druze population in northern israel",

abstract = "Background: Essential tremor (ET) and Parkinson{\textquoteright}s disease (PD) are probably the most common movement disorders. As ethnic differences have been reported in ET, we designed the present study to evaluate the prevalence of ET and that of Parkinson{\textquoteright}s disease (PD) in the Druze villages of northern Israel. Methods: A two-phase, door-to-door survey was undertaken. Residents aged ≥51 years who agreed to participate and answered {\textquoteleft}{\textquoteleft}yes{\textquoteright}{\textquoteright} to tremor or PD-related screening questions and 3% of subjects who screened negative were evaluated. Diagnostic criteria for ET were similar to those used in Sicilian and Spanish studies. PD was diagnosed according to Gelb{\textquoteright}s criteria. Results: The target population consisted of 9,086, the study cohort of 3,980 residents. Tremor was observed in 36 subjects. In 27, the tremor fully met the criteria for ET. The prevalence of ET (age ≥65) was 1.49% (95% CI 0.91–2.07%). PD was diagnosed in 23 subjects. The prevalence of PD (age ≥65) was 1.13 (95% CI 0.62–1.64%). Leucine-rich repeat protein kinase 2 (G2019S mutation) was evaluated in subjects diagnosed with tremor PD and those screened for assessment of the validity of the questionnaire. None carried the mutation. Discussion: The prevalence of ET in the Druze population is low and similar to the prevalence of PD.",

keywords = "Druze, Epidemiology, Essential tremor, Leucine-rich repeat protein kinase 2, Parkinson{\textquoteright}s disease",

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note = "Funding Information: * To whom correspondence should be addressed. E-mail: [email protected] Editor: Elan D. Louis, Columbia UniversityUnited States of America Received: November 29, 2011 Accepted: December 21, 2011 Published: March 22, 2012 Copyright: {\textquoteright} 2012 Aharon-Peretz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution–Noncommercial–No Derivatives License, which permits the user to copy, distribute, and transmit the work provided that the original author(s) and source are credited; that no commercial use is made of the work; and that the work is not altered or transformed. Funding: This study was supported by a research grant from the Israeli Ministry of Science and Technology. Competing Interests: The authors report no conflict of interest. Publisher Copyright: {\textcopyright} 2012 Aharon-Peretz et al.",

year = "2012",

doi = "10.5334/TOHM.90",

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journal = "Tremor and Other Hyperkinetic Movements",

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AU - Aharon-Peretz, Judith

AU - Badarny, Samih

AU - Ibrahim, Raphiq

AU - Gershoni-Baruch, Ruth

AU - Hassoun, Gamal

N1 - Funding Information: * To whom correspondence should be addressed. E-mail: [email protected] Editor: Elan D. Louis, Columbia UniversityUnited States of America Received: November 29, 2011 Accepted: December 21, 2011 Published: March 22, 2012 Copyright: ’ 2012 Aharon-Peretz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution–Noncommercial–No Derivatives License, which permits the user to copy, distribute, and transmit the work provided that the original author(s) and source are credited; that no commercial use is made of the work; and that the work is not altered or transformed. Funding: This study was supported by a research grant from the Israeli Ministry of Science and Technology. Competing Interests: The authors report no conflict of interest. Publisher Copyright: © 2012 Aharon-Peretz et al.

PY - 2012

Y1 - 2012

N2 - Background: Essential tremor (ET) and Parkinson’s disease (PD) are probably the most common movement disorders. As ethnic differences have been reported in ET, we designed the present study to evaluate the prevalence of ET and that of Parkinson’s disease (PD) in the Druze villages of northern Israel. Methods: A two-phase, door-to-door survey was undertaken. Residents aged ≥51 years who agreed to participate and answered ‘‘yes’’ to tremor or PD-related screening questions and 3% of subjects who screened negative were evaluated. Diagnostic criteria for ET were similar to those used in Sicilian and Spanish studies. PD was diagnosed according to Gelb’s criteria. Results: The target population consisted of 9,086, the study cohort of 3,980 residents. Tremor was observed in 36 subjects. In 27, the tremor fully met the criteria for ET. The prevalence of ET (age ≥65) was 1.49% (95% CI 0.91–2.07%). PD was diagnosed in 23 subjects. The prevalence of PD (age ≥65) was 1.13 (95% CI 0.62–1.64%). Leucine-rich repeat protein kinase 2 (G2019S mutation) was evaluated in subjects diagnosed with tremor PD and those screened for assessment of the validity of the questionnaire. None carried the mutation. Discussion: The prevalence of ET in the Druze population is low and similar to the prevalence of PD.

AB - Background: Essential tremor (ET) and Parkinson’s disease (PD) are probably the most common movement disorders. As ethnic differences have been reported in ET, we designed the present study to evaluate the prevalence of ET and that of Parkinson’s disease (PD) in the Druze villages of northern Israel. Methods: A two-phase, door-to-door survey was undertaken. Residents aged ≥51 years who agreed to participate and answered ‘‘yes’’ to tremor or PD-related screening questions and 3% of subjects who screened negative were evaluated. Diagnostic criteria for ET were similar to those used in Sicilian and Spanish studies. PD was diagnosed according to Gelb’s criteria. Results: The target population consisted of 9,086, the study cohort of 3,980 residents. Tremor was observed in 36 subjects. In 27, the tremor fully met the criteria for ET. The prevalence of ET (age ≥65) was 1.49% (95% CI 0.91–2.07%). PD was diagnosed in 23 subjects. The prevalence of PD (age ≥65) was 1.13 (95% CI 0.62–1.64%). Leucine-rich repeat protein kinase 2 (G2019S mutation) was evaluated in subjects diagnosed with tremor PD and those screened for assessment of the validity of the questionnaire. None carried the mutation. Discussion: The prevalence of ET in the Druze population is low and similar to the prevalence of PD.

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KW - Parkinson’s disease

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DO - 10.5334/TOHM.90

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SN - 2160-8288

VL - 2

JO - Tremor and Other Hyperkinetic Movements

JF - Tremor and Other Hyperkinetic Movements

ER -

Essential tremor prevalence is low in the druze population in northern israel

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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